| 人参蛤蚧散加味联合穴位注射治疗对稳定期COPD患者免疫功能、IL-2及sIL-2R的影响 |
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| 引用本文： | 温秀梅,赵峻峰,陈中明.人参蛤蚧散加味联合穴位注射治疗对稳定期COPD患者免疫功能、IL-2及sIL-2R的影响[J].中华全科医学,2018,16(4):630-633. |
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| 作者姓名： | 温秀梅 赵峻峰 陈中明 |
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| 作者单位： | 1. 浙江中医药大学附属第三医院急诊科, 浙江 杭州 310005; |
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| 基金项目： | 浙江省医学会临床科研基金项目(2015ZYC-A32) |
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| 摘 要： | 目的 探讨人参蛤蚧散加味联合穴位注射治疗对稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者免疫功能及白介素(interleukin,IL)-2、白介素2受体(soluble interleukin-2 receptor,sIL-2R)的影响。 方法 采用随机数字法将2015年2月-2016年10月在浙江中医药大学附属第三医院就诊的130例稳定期COPD患者随机分为2组,每组65例。对照组给予西医治疗,观察组在对照组基础上给予喘可治注射液足三里与人参蛤蚧散加味治疗。比较2组患者肺功能、免疫功能、IL-2和sIL-2R、生活质量。 结果 治疗后,2组FEV1、FEV1%、FVC均明显升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后,2组CD3+、CD4+、CD4+/CD8+均显著升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后,2组IL-2显著升高(P<0.05),且观察组高于对照组(P<0.05);2组sIL-2R明显降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组呼吸症状、活动情况、疾病影响及总评分均明显降低(P<0.05),且观察组显著低于对照组(P<0.05)。 结论 人参蛤蚧散加味联合穴位注射治疗可有效改善稳定期COPD患者的免疫功能,其机制可能是通过改善IL-2和sIL-2R来实现,进而提升患者的肺功能和生活质量。
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| 关 键 词： | 慢性阻塞性肺疾病 人参蛤蚧散加味 穴位注射 免疫功能 生活质量 |
| 收稿时间： | 2017-06-05 |
Effects of Renshen Hajie power combined acupoint injection on immune function,IL-2 and sIL-2R of patients with stable COPD |
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| Affiliation: | Emergency Department, the Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang 310005, China |
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| Abstract: | Objective To investigate the effect of Renshen Hajie power combined acupoint injection on immune function, IL-2 and sIL-2R of patients with stable COPD. Methods A total of 130 patients with stable COPD were randomly divided into two groups, each group 65 cases. The control group was given Western medicine treatment, and the observation group was given Renshen Hajie power combined acupoint injection based on control group. The lung function, immune function, IL-2 and sIL-2R, and life quality of two groups were compared. Results After treatment, FEV1, FEV1% and FVC of two groups were significantly increased (P<0.05), and observation group was higher than control group (P<0.05). After treatment, CD3+, CD4+, CD4+/CD8+ of two groups were significantly increased (P<0.05), and the observation group was higher than control group (P<0.05). After treatment, IL-2 of two groups were significantly increased (P<0.05), and the observation group was higher than control group (P<0.05). After treatment, sIL-2R of two groups were significantly decreased (P<0.05), and the observation group was lower than control group (P<0.05). After treatment, the respiratory symptoms, activities status, disease influence and total score of two groups were significantly reduced (P<0.05), and the observation group was significantly lower than the control group (P<0.05). Conclusion Renshen Hajie power combined acupoint injection could effectively improve the immune function of patients with stable COPD. The mechanism might be achieved by improving IL-2 and sIL-2R, thereby enhancing lung function and life quality of patients. |
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