| 汉坦病毒及其与宿主基因相互作用研究进展 |
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| 引用本文： | 杨其松,张天琛,刘晓青,谢昀,朱蒙曼,胡国良.汉坦病毒及其与宿主基因相互作用研究进展[J].中华疾病控制杂志,2018,22(7):751-754. |
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| 作者姓名： | 杨其松 张天琛 刘晓青 谢昀 朱蒙曼 胡国良 |
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| 作者单位： | 1. 南昌大学公共卫生学院流行病学教研室, 江西 南昌 330000; |
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| 基金项目： | 江西省青年科学基金项目（20171BAB215051） |
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| 摘 要： | 近年来，随着分子生物学等技术的不断发展，对汉坦病毒（hantavirus，HV）基因的研究越来越深入，国内外对不同型别HV与自然宿主、生态环境和进化方面进行了大量的研究，发现HV的流行及疫区演变与病毒和宿主长期相互作用联系紧密。由于HV基因分型较多，在全球分布广泛，HV不同血清型甚至同一血清型不同病毒株间存在核酸序列的差异，不同分型的HV基因片段往往会发生重组，这在HV及其与宿主动物基因相互作用中起着重要作用，并对病毒的致病性及其相关疾病的临床诊断与治疗及流行等方面具有重要意义。因此，本研究结合国内外HV研究进展对其流行现况、生物学特性及与宿主基因相互作用等方面加以综述。
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| 关 键 词： | 汉坦病毒 肾综合征出血热 宿主 |
| 收稿时间： | 2017-11-14 |
Research progress of Hantavirus and its interaction with host genes |
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| Affiliation: | 1. Epidemiology Teaching and Research Section, Public Health School of Nanchang University, Nanchang 330000, China;2. Department of Communicable Diseases Control, Jiangxi Province Center for Disease Control and Prevention, Nanchang 330029, China |
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| Abstract: | In recent years, the research on hantavirus gene is getting deeper and deeper with the development of molecular biology and other technologies. A lot of research on different types of hantavirus and rodent hosts, ecological environment and evolution has been carried out at home and abroad. It was found that the prevalence and evolution of hantavirus were closely related to the long-term interaction between hantavirus and hosts.Hantavirus has many genotypes and it is widely distributed all over the world. There were differences in nucleic acid sequence among different serotypes of hantavirus and different hantavirus strains of the same serotype, and the gene fragments of hantavirus of different genotypes were often recombined, which plays an important role in the interaction between hantavirus and host genes. Meanwhile, it is of great significance to the pathogenicity of hantavirus and the clinical diagnosis, treatment and epidemic of the related diseases. Therefore, in this study, the current epidemic status, biological characteristics and interaction with host genes of hantavirus were reviewed. |
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