| 甲胎蛋白与自噬在肝癌发生发展中的作用及其相互关系 |
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| 引用本文： | 赵 伟,戴朝六.甲胎蛋白与自噬在肝癌发生发展中的作用及其相互关系[J].现代肿瘤医学,2015,0(17):2536-2539. |
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| 作者姓名： | 赵 伟 戴朝六 |
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| 作者单位： | 中国医科大学附属盛京医院肝胆脾外科，辽宁 沈阳 110004 |
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| 基金项目： | 辽宁省自然科学基金项目（编号:2013021072） |
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| 摘 要： | 甲胎蛋白（AFP）作为临床诊断肝癌最常用的肿瘤标志物，有抑制免疫、促进细胞生长、抑制癌细胞凋亡的作用。自噬是一种维持细胞生存的重要途径之一，其与肝癌的发生发展及治疗有着密切联系，对肝癌既有抑制又有促进作用。PI3K/AKT作为两者共有的信号通路，它们是否有着相互关系来促进肝癌的发展尚需进一步研究。
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| 关 键 词： | 自噬 AFP 肝癌 凋亡 信号通路 |
The effect and relation of AFP and autophagy in occurrence and development of hepato-cellular carcinoma |
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| Zhao Wei,Dai Chaoliu.The effect and relation of AFP and autophagy in occurrence and development of hepato-cellular carcinoma[J].Journal of Modern Oncology,2015,0(17):2536-2539. |
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| Authors: | Zhao Wei Dai Chaoliu |
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| Affiliation: | Department of Hepatobiliary and Splenic Surgery,The Affiliated Shengjing Hospital of China Medical University，Liaoning Shenyang 110004,China. |
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| Abstract: | AFP is used to diagnose hepatocellular carcinoma,which has the function of inhibiting immunity,promoting growth and inhibiting apoptosis.Autophagy is an important process of maintaining the cellular living，which has closed relation with occurrence,development and treatment of hepatocellular carcinoma，and it has function of inhibiting and promoting.PI3K/AKT is the common signal path of AFP and autophagy,whether they have the mutual relation to promote the development of hepatocellular carcinoma needs more research. |
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| Keywords: | autophagy AFP hepatocellular carcinoma apoptosis signal path |
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