| 白细胞和C反应蛋白及红细胞压积在成人急性感染性腹泻中的应用价值 |
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| 引用本文： | 杨荻,黄育红,张斌.白细胞和C反应蛋白及红细胞压积在成人急性感染性腹泻中的应用价值[J].中华全科医学,2021,9(3):375-378. |
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| 作者姓名： | 杨荻 黄育红 张斌 |
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| 作者单位： | 合肥市第三人民医院感染性疾病科，安徽 合肥 230022 |
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| 基金项目： | 安徽省自然科学基金项目1708085MH0117 |
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| 摘 要： | 目的 探讨白细胞(WBC)、C反应蛋白(CRP)及红细胞压积(HCT)在成人急性感染性腹泻中的应用价值。 方法 收集2014年4月—2018年10月合肥市第三人民医院收治的急性感染性腹泻患者共90例，根据疾病导致的脱水症状分轻、中、重3组(各30例)，患者均进行抗生素治疗，检查治疗前后WBC、CRP、HCT水平以及腹痛、恶心呕吐、发热、乏力发生率。用Pearson法分析3项指标与脱水程度、止泻时间的关系。 结果 3组治疗前WBC、CRP及HCT差异均有统计学意义(F=23.092、3.998、8.905，均P＜0.05)，其中轻度组WBC、CRP及HCT水平最低，重度组水平最高(P＜0.05)。3组治疗后WBC、CRP及HCT差异均有统计学意义(F=13.966、4.031、5.435，均P＜0.05)，其中轻度组WBC、CRP及HCT水平最低，重度组水平最高(P＜0.05)。重度组止泻时间(10.57±4.36)d]、抗生素治疗时间(10.71±3.92)d]最长，且重度组的腹痛、恶心呕吐、发热、乏力的发生率最高(P＜0.05)。WBC与脱水程度、止泻时间均为正相关(r=0.767、0.813，均P＜0.05)；CRP与脱水程度、止泻时间均为正相关(r=0.829、0.802，均P＜0.05)；HCT与脱水程度、止泻时间均为正相关(r=0.886、0.823，P＜0.05)。 结论 WBC、CRP及HCT可以预测细菌培养阴性的急性感染性腹泻患者脱水程度及预后情况，为指导治疗和避免抗生素过度使用提供参考。
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| 关 键 词： | 腹泻 白细胞 红细胞压积 C反应蛋白 |
| 收稿时间： | 2020-03-26 |
Application value of white blood cell,C-reactive protein and hematocrit in adult acute infectious diarrhea |
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| Affiliation: | Department of Infectious Diseases, the Third People's Hospital of Hefei, Hefei, Anhui 230022, China |
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| Abstract: | Objective To explore the application value of white blood cell (WBC), C-reactive protein (CRP) and hematocrit (HCT) in adult's acute infectious diarrhea. Methods A total of 90 patients with acute infectious diarrhea admitted to our hospital from April 2014 to October 2018 were collected. According to the dehydration symptoms caused by the disease, they were divided into three groups of mild, medium and severe group (30 cases each). All patients were treated with antibiotics. WBC, CRP, HCT, abdominal pain, nausea and vomiting, fever and fatigue were examined before and after treatment. Pearson's method was used to analyze the relationship among the three indexes, dehydration degree and antidiarrheal time. Results The differences of WBC, CRP and HCT in the three groups before treatment were statistically significant (F=23.092, 3.998, 8.905, all P < 0.05). Among them, the WBC, CRP and HCT levels were the lowest in the mild group and the highest in the severe group (P < 0.05). The differences of WBC, CRP and HCT in the three group after treatment were statistically significant (F=13.966, 4.031, 5.435, all P < 0.05). Among them, the WBC, CRP and HCT levels were the lowest in the mild group, and the highest in the severe group (P < 0.05). The antidiarrheal time (10.57±4.36) d] and antibiotic treatment time (10.71±3.92) d] were the longest in the severe group, and the incidence of abdominal pain, nausea and vomiting, fever and fatigue were the highest in the severe group (P < 0.05). WBC was positively correlated with dehydration degree and antidiarrheal time (r=0.767, 0.813, all P < 0.05), CRP was positively correlated with dehydration degree and antidiarrheal time (r=0.829, 0.802, all P < 0.05), HCT was positively correlated with dehydration degree and antidiarrheal time (r=0.886, 0.823, all P < 0.05). Conclusion WBC, CRP and HCT can predict the dehydration degree and prognosis of patients with negative bacterial culture, and provide reference for guiding treatment and avoiding excessive use of antibiotics. |
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