| 骨标志物在乳腺癌骨转移诊断与疗效观察中的作用 |
| |
| 引用本文： | 迟伟群,王福莉,隋晓凤,于晓斐,张超民,姚玉虹.骨标志物在乳腺癌骨转移诊断与疗效观察中的作用[J].实用肿瘤学杂志,2012,26(5):414-417. |
| |
| 作者姓名： | 迟伟群 王福莉 隋晓凤 于晓斐 张超民 姚玉虹 |
| |
| 作者单位： | 1.哈尔滨医科大学附属第四医院检验科(哈尔滨 150001);2.哈尔滨市第五医院 |
| |
| 基金项目： | 基金项目：黑龙江省卫生厅项目（2010-121） |
| |
| 摘 要： | 目的 探讨I型胶原交联羧基氨基端肽(β-Cross Laps)和总骨1型前胶原氨基端延长肽(P1NP)在乳腺癌骨转移诊断与疗效观察中的临床价值。方法 运用电化学发光法对β-Cross Laps、P1NP、CA15-3进行定量检测。57例乳腺癌骨转移患者按转移灶多少分为2组,分别为骨显像轻度异常组(Ⅰ组)36例与骨显像明显异常组(Ⅱ组)21例。结果 骨转移组β-Cross Laps、P1NP两种血清标志物较无骨转移组与对照组明显升高,差异具有统计学意义(P＜0.01),且治疗后两种指标明显低于治疗前水平(P＜0.05),随转移灶增加两种标志物水平也有升高趋势,差异具有统计学意义(P＜0.01)。而各组间及治疗前后CA15-3无显著变化(P＞0.05)。骨标志物β-Cross Laps、P1NP对乳腺癌骨转移的诊断灵敏度分别达到71.25%与64.05%,特异性分别达到88.00%与81.99%,均高于骨显像所显示结果的50.32%和61.17%。结论 血清骨标志物β-Cross Laps、P1NP水平可以反映乳腺癌骨转移患者病情变化,并可以运用于疗效监测,有较好的临床应用价值。
|
| 关 键 词： | I型胶原交联羧基氨基端肽 总骨1型前胶原氨基端延长肽 乳腺癌骨转移 |
| 收稿时间： | 2012-03-20 |
The effectiveness of bone marker in the diagnosing and observing therapeutic effect of bone metastatic carcinoma |
| |
| CHI Weiqun,WANG Fuli,SUI Xiaofeng,YU Xiaofei,ZHANG Chaomin,YAO Yuhong.The effectiveness of bone marker in the diagnosing and observing therapeutic effect of bone metastatic carcinoma[J].Journal of Practical Oncology,2012,26(5):414-417. |
| |
| Authors: | CHI Weiqun WANG Fuli SUI Xiaofeng YU Xiaofei ZHANG Chaomin YAO Yuhong |
| |
| Affiliation: | 1.Department of Clinical Lab,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China;2.The Fifth Hospital of Harbin |
| |
| Abstract: | Objective To investigate the clinical value of β -Cross Laps and P1NP in diagnosing and observing therapeutic effect of bone metastatic carcinoma. Methods Detecting β - Cross Laps, P1NP, CA15 - 3 quantitatively using the electrochemiluminescence. All the 57 patient with bone metastatic carcinoma were divided into two grouos. One（ I ）for 36 were with lighter abnormality of bone imaging. The other（ II ）were remarkableness of bone imaging. Results The concentrations of β - Cross Laps and P1NP in the group one are obviously higher than the group two and control group. The discrepancy have the statistical significance （P 〈 0.01 ）. And the concentrations of the two marker aftertherapy are also obviously lower than the concentrations before therapy （P 〈 0.05 ）, the concentrations of the two marker are also having the increasing tendency followed by the creasing of metastasis. The discrepancy have the statistical significance （ P 〈 0.01 ）. There are no significantly changes of CA15 -3 in different groups（P 〉0.05）. The sensibility of β - Cross Laps and P1NP might reached at 71.25% and 64.05%. The specificity of them might reached at 88.0% and 81.99%. Both are higher than the results of bone imaging for 50.32% and 61.17%. Conclusion The concentrations of β - Cross Laps and P1NP might reflect the alleosis of the patients of bone metastatic carcinoma. It can be used for monitoring therapeutic effect, having better clinical application worth. |
| |
| Keywords: | β- Cross Laps P1NP Bone metastatic carcinoma |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《实用肿瘤学杂志》浏览原始摘要信息 |
|
点击此处可从《实用肿瘤学杂志》下载全文 |
|
