| PD-1/PD-L1信号通路在结直肠癌免疫逃逸及其治疗中作用的研究进展 |
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| 引用本文： | 陈秋霞,林羽赫,张 咪,陈 怡,周霄霄,王 颖.PD-1/PD-L1信号通路在结直肠癌免疫逃逸及其治疗中作用的研究进展[J].现代肿瘤医学,2018,0(13):2133-2138. |
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| 作者姓名： | 陈秋霞 林羽赫 张 咪 陈 怡 周霄霄 王 颖 |
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| 作者单位： | 中国医科大学附属盛京医院肿瘤科，辽宁 沈阳 110000 |
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| 摘 要： | 结直肠癌是常见的消化系统肿瘤。近年来，免疫治疗是继放化疗及靶向治疗之后，结直肠癌治疗领域的新方向。而作为T细胞免疫反应的协同刺激信号通路，程序性死亡分子1（programmed death-1，PD-1）/PD-1配体（PD-1 ligand，PD-L1)信号通路在肿瘤的免疫治疗中起着至关重要的作用。PD-1/PD-L1信号通路被激活后，可参与肿瘤的免疫逃逸，与肿瘤的发生、发展密切相关。体内外实验证实，阻断该通路可增强机体内源性抗肿瘤免疫效应。本文就PD-1/PD-L1信号通路及其阻滞剂在结直肠癌领域中的研究进展作一综述。
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| 关 键 词： | PD-1/PD-L1 结直肠癌 免疫逃逸 免疫治疗 |
Advances of PD-1/PD-L1 signaling pathway in immune escape and treatment for colorectal cancer |
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| Chen Qiuxia,Lin Yuhe,Zhang Mi,Chen Yi,Zhou Xiaoxiao,Wang Ying.Advances of PD-1/PD-L1 signaling pathway in immune escape and treatment for colorectal cancer[J].Journal of Modern Oncology,2018,0(13):2133-2138. |
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| Authors: | Chen Qiuxia Lin Yuhe Zhang Mi Chen Yi Zhou Xiaoxiao Wang Ying |
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| Affiliation: | Department of Oncology，Affiliated to Shengjing Hospital，China Medical University，Liaoning Shenyang 110000，China. |
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| Abstract: | Circulation of tumor cells (CTC) can predict the prognosis of metastatic breast cancer，but its ability to improve the prognosis of patients in clinical trials has not been confirmed.The current study focuses on the molecular characterization of CTC as a "substitute" for tumor tissue to assess the expression of cancer genome and its evolution during treatment in a noninvasive manner.There is epithelial-mesenchymal transition (EMT) in CTC，which is characterized by a deletion of epithelial markers.EMT process can exist in the invasive and drug-resistant cells，its counting and characterization，can cause tumor recurrence and progression，has a high clinical value.This article explores the heterogeneity of circulating tumor cells and the role of metastatic breast epithelial-mesenchymal transition.Making it a routine target for monitoring the metastasis and prognosis of breast cancer patients and helping to clarify the mechanism of metastasis and to find new targets for breast cancer with transfer therapy. |
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| Keywords: | circulatory tumor cells heterogeneity metastatic breast cancer epithelial-mesenchymal transition |
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