| 乳腺浸润性微乳头状癌组织中Twist和E-cadherin的表达及其意义 |
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| 引用本文： | 陈海霞,王维娜,姬文莉,岳 娜,李文婷,张银华. 乳腺浸润性微乳头状癌组织中Twist和E-cadherin的表达及其意义[J]. 现代肿瘤医学, 2018, 0(20): 3237-3241. DOI: 10.3969/j.issn.1672-4992.2018.20.016 |
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| 作者姓名： | 陈海霞 王维娜 姬文莉 岳 娜 李文婷 张银华 |
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| 作者单位： | 新疆医科大学附属肿瘤医院病理科，新疆 乌鲁木齐 830011 |
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| 基金项目： | 新疆医科大学科研创新基金(编号:XYDCX201551) |
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| 摘 要： | 目的:探讨乳腺浸润性微乳头状癌（IMPC）组织中Twist和E-cadherin的表达及其意义。方法:应用免疫组织化学方法检测56例乳腺IMPC和100例乳腺浸润性导管癌（IDC）组织中Twist和E-cadherin的表达，分析其与乳腺IMPC临床病理特征之间关系及其相互关系。结果:乳腺IMPC脉管侵犯和淋巴结转移阳性率分别为91.1%（51/56）和82.1%（46/56），明显高于IDC组的43.0%（43/100）和51.0%（51/100），差异有统计学意义（P＜0.05)；而年龄及肿块大小乳腺IMPC与IDC组比较，差异无统计学意义（P＞0.05）。乳腺IMPC和IDC组织中Twist表达阳性率分别为76.8%（43/56）和61.0%（61/100），差异有统计学意义（P＜0.05），而E-cadherin的阳性表达率分别为73.2%（41/56）和68.0%（68/100），差异无统计学意义（P＞0.05)。Twist在乳腺IMPC组织中阳性表达与脉管侵犯、淋巴结转移及ER表达相关，差异有统计学意义（P＜0.05）；而与年龄、民族、肿块大小、组织学类型、微乳头比例、PR及Her-2表达无关，差异均无统计学意义（P＞0.05）。E-cadherin在乳腺IMPC组织中阳性表达与淋巴结转移和ER表达相关，差异有统计学意义（P＜0.05）；而与年龄、民族、肿块大小、组织学类型、微乳头比例、脉管侵犯、PR及Her-2表达无关，差异均无统计学意义（P＞0.05）。Spearman 相关性分析表明，Twist与E-cadherin在乳腺IMPC组织中的表达呈负相关（P＜0.05）。结论:乳腺IMPC组织中Twist与E-cadherin均高表达，且其表达对肿瘤细胞的上皮间质转化（EMT）有重要意义，促进了肿瘤细胞的侵袭和转移，对乳腺IMPC的发生、发展及判断预后有指导作用。
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| 关 键 词： | 乳腺浸润性微乳头状癌 Twist E-cadherin 上皮间质转化 免疫组织化学染色 |
The significance of Twist and E-cadherin expression in invasive micro-papillary carcinoma of the breast |
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| Chen Haixia,Wang Weina,Ji Wenli,Yue Na,Li Wenting,Zhang Yinhua. The significance of Twist and E-cadherin expression in invasive micro-papillary carcinoma of the breast[J]. Journal of Modern Oncology, 2018, 0(20): 3237-3241. DOI: 10.3969/j.issn.1672-4992.2018.20.016 |
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| Authors: | Chen Haixia Wang Weina Ji Wenli Yue Na Li Wenting Zhang Yinhua |
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| Affiliation: | Pathology Department，Affiliated Tumor Hospital of Xinjiang Medical University，Xinjiang Urumqi 830011，China. |
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| Abstract: | Objective:To investigate the expression and significance of Twist and E-cadherin in invasive micro-papillary carcinoma（IMPC） of the breast.Methods:The expression of Twist and E-cadherin was observed by immunohistochemical technique for 56 cases of IMPC of the breast and 100 cases infiltrating ductal carcinoma（IDC) tissues to analyse the relationship between the protein and clinico-pathological characteristics and their interrelationship.Results:The positive rate of vascular invasion and lymph node metastasis in IMPC were 91.1%（51/56) and 82.1%（46/56) higher than IDC 43.0%（43/100) and 51.0%（51/100),the difference was statistically significant（P＜0.05),while age and tumor size compared with IDC,the difference was not statistically significant（P＞0.05).The positive rates of Twist expression in IMPC and IDC were 76.8%（43/56) and 61.0%（61/100) respectively,the difference was statistically significant（P＜0.05),while the positive rate of E-cadherin expression were 73.2%（41/56) and 68.0%（68/100) respectively,the difference was no statistically significant difference（P＞0.05).The expression of Twist were significant difference with vascular invasion,lymph node metastasis and estrogen receptor（P＜0.05）,but were not significant difference with age,nation,tumor size,histological type,micro-papillary ratio,progesterone receptor and Her-2（P＞0.05）.The expression of E-cadherin were significant difference with lymph node metastasis and estrogen receptor（P＜0.05）,but were not significant difference with age,nation,tumor size,histological type,micro-papillary ratio,vascular invasion,progesterone receptor and Her-2（P＞0.05）.The spearman correlation analysis showed that the expression of Twist and E-cadherin showed negative correlation（P＜0.05）.Conclusion:The expression of Twist and E-cadherin in IMPC of the breast is involved in epithelial mesenchymal transition of tumor cell,and promotes the invasiveness and metastasis of tumor cell.It may play an important role in the occurrence,development and judge prognosis of IMPC of the breast. |
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| Keywords: | invasive micro-papillary carcinoma of the breast Twist E-cadherin epithelial mesenchymal transition immunohistochemistry |
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