| BMI及临床特征对不同生理阶段乳腺癌复发转移的影响分析 |
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| 引用本文： | 李芹,李卉,陶苹,李卉,谭婧,李佳圆.BMI及临床特征对不同生理阶段乳腺癌复发转移的影响分析[J].现代预防医学,2016,0(14):2563-2567. |
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| 作者姓名： | 李芹 李卉 陶苹 李卉 谭婧 李佳圆 |
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| 作者单位： | 1. 四川大学华西公共卫生学院（华西第四医院），四川 成都 610041；2. 四川省肿瘤医院，四川 成都 610000；3. 重庆医科大学附属第一医院，重庆 400042 |
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| 摘 要： | 目的 探讨体重指数(BMI)及临床特征对不同生理阶段乳腺癌复发转移的影响。方法 回顾性收集四川省肿瘤医院1999年至2010年收治的女性原发性乳腺癌743例。根据绝经状态和年龄将患者划分为育龄期、围绝经期、绝经后3组，分析影响各组乳腺癌无病生存期(DFS)的因素。结果 多因素分析发现，高BMI(23.0~29.9 kg/m2)和低BMI(< 18.5 kg/m2)均能降低绝经后患者的DFS (HR高BMI = 2.60, 95%CI: 1.06~6.37；HR低BMI = 6.92, 95%CI: 1.93~24.81)；三阴降低围绝经和绝经后患者的DFS (HR = 4.78, 95%CI: 1.06~21.58；HR = 2.64, 95%CI: 1.33~5.28)；淋巴结转移数≥4个降低育龄患者的DFS(HR = 4.08, 95%CI: 1.52~10.97 )。结论 BMI及三阴对不同生理阶段乳腺癌预后均有影响，尤其是高低BMI均能降低患者的无病生存期，提示患者应保持适当体重，减少复发转移风险。
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| 关 键 词： | 乳腺癌 复发转移 体重指数(BMI) |
Analysis of the influence of body mass index (BMI) and clinical characteristics on recurrence and metastasis of breast cancer at different physiological stages |
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| LI Qin,LI Hui,TAO Ping,LI Hui,TAN Jing,LI Jia-yuan.Analysis of the influence of body mass index (BMI) and clinical characteristics on recurrence and metastasis of breast cancer at different physiological stages[J].Modern Preventive Medicine,2016,0(14):2563-2567. |
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| Authors: | LI Qin LI Hui TAO Ping LI Hui TAN Jing LI Jia-yuan |
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| Affiliation: | *West China School of Public Health, West China Fourth University Hospital, Sichuan University, Chengdu, Sichuan 610041, China |
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| Abstract: | Objective The study aimed to investigate the influence of body mass index (BMI) and clinical characteristics on recurrence and metastasis of breast cancer at different physiological stages. Methods 743 cases of primary breast cancer hospitalized at the Cancer Hospital of Sichuan Province from 1999 to 2010 were retrospectively collected, and divided according to their menopausal statuses and ages into a child-bearing group, a perimenopause group, and a postmenopause group. The influencing factors for disease-free survival (DFS) of breast cancer among different groups were analyzed. Results Multivariate analysis showed that high BMI (23.0-29.9kg/m2) and low BMI (<18.5kg/m2) were associated with deceased DFS among the postmenopausal patients (HR high BMI=2.60, 95%CI: 1.06~6.37; HR low BMI= 6.92, 95%CI: 1.93-24.81); triple negativity was associated with decreased DFS among the perimenopausal and postmenopausal patients (HR=4.78, 95%CI: 1.06-21.58; HR=2.64, 95%CI: 1.33-5.28); and having metastasis at 4 or more lymph nodes was associated with decreased DFS among the patients at child-bearing ages (HR=4.08, 95%CI: 1.52-10.97). Conclusion BMI and triple negativity affect prognosis of breast cancer patients at all physiological stages. Especially, high and low BMIs reduce disease-free survival of the patients. Therefore, breast cancer patients should be reminded to maintain a proper body weight to reduce the risk of recurrence or metastasis. |
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| Keywords: | Breast cancer Recurrence and metastasis Body mass index (BMI) |
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