| 布地奈德固体脂质纳米粒肺部给药系统的制备和评价(英文) |
| |
| 引用本文： | 张沛然,涂盈锋,王硕,王艺辉,谢英,李淼,金义光.布地奈德固体脂质纳米粒肺部给药系统的制备和评价(英文)[J].中国药学,2011,20(4):390-396. |
| |
| 作者姓名： | 张沛然 涂盈锋 王硕 王艺辉 谢英 李淼 金义光 |
| |
| 作者单位： | 北京大学医学部药学院药剂学系;瑞士巴塞尔大学药学院;北京放射医学研究所; |
| |
| 基金项目： | National Basic Research Program of China (973 Program No 2009CB930300); National Integrity Innovational Technology Platform of New Drug and Research and Development (Grant No 2009ZX09310-001) |
| |
| 摘 要： | 为改善布地奈德的溶解度和吸收,制备并评价了布地奈德固体脂质纳米粒(BUD-SLNs)。通过计算部分溶解度参数选择了单硬脂酸甘油酯作为脂材。经处方优化采用乳化-超声分散的方法制备的BUD-SLNs,包封率为(97.77±2.60)%;平均粒径是147.3nm,粒径分布均匀(PDI=0.228)。透射电镜下可见圆整颗粒。差热分析和X射线衍射实验的结果表明BUD以分子形式分散在SLNs中,体外释放结果表明BUD-SLNs符合双相动力学方程,属于均相骨架结构。研究结果为BUD-SLNs在肺部给药奠定了基础。
|
| 关 键 词： | 布地奈德 固体脂质纳米粒 肺部给药 制备 评价 |
Preparation and characterization of budesonide-loaded solid lipid nanoparticles for pulmonary delivery |
| |
| Pei-Ran Zhang,Ying-Feng Tu,Shuo Wang,Yi-Hui Wang,Ying Xie,Miao Li,Yi-Guang Jin.Preparation and characterization of budesonide-loaded solid lipid nanoparticles for pulmonary delivery[J].Journal of Chinese Pharmaceutical Sciences,2011,20(4):390-396. |
| |
| Authors: | Pei-Ran Zhang Ying-Feng Tu Shuo Wang Yi-Hui Wang Ying Xie Miao Li Yi-Guang Jin |
| |
| Affiliation: | Pei-Ran Zhang~1,Ying-Feng Tu~1,Shuo Wang~2,Yi-Hui Wang~1,Ying Xie~(1*),Miao Li~(3*),Yi-Guang Jin~3 1.Department of Pharmaceutics,School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing 100191,China 2.School of Pharmaceutics,Basel University,Basel CH-4056,Switzerland 3.Beijing Institute of Radiation Medicine,Beijing 100850,China |
| |
| Abstract: | |
| |
| Keywords: | Budesonide Solid lipid nanoparticles Pulmonary drug delivery Preparation Characterization |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国药学》浏览原始摘要信息 |
|
点击此处可从《中国药学》下载全文 |
|
