| 2型糖尿病患者并发轻度认知功能障碍危险因素的Meta分析 |
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| 引用本文： | 陈昕羽,高静,吴晨曦,柏丁兮,朱琳.2型糖尿病患者并发轻度认知功能障碍危险因素的Meta分析[J].现代预防医学,2021,0(21):4022-4027. |
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| 作者姓名： | 陈昕羽 高静 吴晨曦 柏丁兮 朱琳 |
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| 作者单位： | 成都中医药大学护理学院，四川 611137 |
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| 摘 要： | 目的 系统评价2型糖尿病患者并发轻度认知功能障碍的危险因素。方法 检索CNKI、WanFang、VIP、CBM、Medline(PubMed)、EMbase、Web of Science和The Cochrane Library 数据库从建库至2020年12月2日有关2型糖尿病患者并发轻度认知功能障碍危险因素的所有文献后进行Meta分析。结果 共纳入文献18篇，研究对象3083例。各危险因素的合并OR(95%CI)为:年龄1.20(1.09,1.33)、文化程度0.67(0.55,0.82)、吸烟史1.41(0.69,2.89)、糖尿病病程1.17(1.06,1.29)、糖化血红蛋白(HbA1c)1.33(1.09,1.62)、空腹血葡萄糖(fasting blood glucose,FBG)0.88(0.75,1.03)、空腹血清C肽(Fasting c-peptide,FCP)0.41(0.16,1.04)、餐后2h血糖(2h plasma glucose,2hPG)1.90(0.52,6.87)、低密度脂蛋白胆同醇(LDL-C)1.42(1.26,1.59)、超敏C反应蛋白(high sensitive C reactive protein,hs-CRP)1.52(1.06,2.20)、胰岛素抵抗指数(HOMA-IR)1.00(0.48,2.08)、冠心病2.57(1.93,3.43)、高血压2.58(1.62,4.13)、周围神经病变1.10(0.10,12.57)。结论 高龄、文化程度低、糖尿病病程长、高HbA1c、高LDL-C、高hs-CRP、冠心病、高血压是2型糖尿病患者并发轻度认知功能障碍的主要危险因素。
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| 关 键 词： | 2型糖尿病 轻度认知功能障碍 危险因素 Meta分析 |
Risk factors of mild cognitive impairment in type 2 diabetes mellitus: a Meta-analysis |
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| CHEN Xin-yu,GAO Jing,WU Chen-xi,BAI Ding-xi,ZHU Lin.Risk factors of mild cognitive impairment in type 2 diabetes mellitus: a Meta-analysis[J].Modern Preventive Medicine,2021,0(21):4022-4027. |
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| Authors: | CHEN Xin-yu GAO Jing WU Chen-xi BAI Ding-xi ZHU Lin |
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| Affiliation: | School of Nursing, Chengdu University of TCM, Sichuan 611137, China |
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| Abstract: | To systematically assess the risk factors and connection strength of mild cognitive impairment in T2 DM patients, so as to provide basis for prevention decision. Methods CNKI, WanFang, VIP, CBM, PubMed, EMbase, Web of Science and The Cochrane Library Data databases were searched to collect studies on the risk factors of mild cognitive impairment in T2 DM patients from inception to December 2, 2020. Then Meta-analysis was conducted. Results A total of 18 studies involving 3 083 subjects were contained. The combined OR(95%CI) results from meta-analysis were: age 1.20(1.09, 1.33), degree of education 0.67(0.55, 0.82), smoking history 1.41(0.69, 2.89), course of diabetes 1.17(1.06, 1.29), HbA1 c 1.33(1.09, 1.62), fasting blood glucose(FBG) 0.88(0.75, 1.03), fasting c-peptide(FCP) 0.41(0.16, 1.04), 2 h plasma glucose(2 hPG) 1.90(0.52, 6.87), low density lipoprotein cholesterol(LDL-C) 1.42(1.26, 1.59), high sensitive C reactive protein(hs-CRP) 1.52(1.06, 2.20), HOMA-IR 1.00(0.48, 2.08), coronary heart disease 2.57(1.93, 3.43), hypertension 2.58(1.62, 4.13), diabetic peripheral neuropathy(DPN) 1.10(0.10, 12.57). Conclusion Age, low degree of education, long course of diabetes, high HbA1 c value, high LDL-C value, high hs-CRP level, coronary heart disease, and hypertension are the most important risk factors to identify and predict MCI in T2 DM patients. |
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| Keywords: | Type 2 Diabetes mellitus MCI Risk factor Meta-analysis |
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