| 聚乙烯亚胺-肝素涂层改性聚氯乙烯与表征 |
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| 引用本文： | 李 亮,魏端丽,曹南南,汪 洋.聚乙烯亚胺-肝素涂层改性聚氯乙烯与表征[J].武汉工程大学学报,2014(5):34-37. |
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| 作者姓名： | 李 亮 魏端丽 曹南南 汪 洋 |
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| 作者单位： | 武汉工程大学材料科学与工程学院,湖北武汉430074 |
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| 基金项目： | 湖北省自然科学基金（2012FFA021） |
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| 摘 要： | 为了改善医用聚氯乙烯材料的生物相容性和抗凝血性,采用新型肝素涂层技术对医用聚氯乙烯材料表面进行改性,研究了涂层中肝素的稳定性.利用聚乙烯亚胺-肝素结合的方法,将肝素涂层固定在医用聚氯乙烯材料表面.使用傅里叶红外光谱仪对其进行测试,绘制肝素钠和聚乙烯亚胺-肝素复合物的标准浓度曲线,通过分光光度法测定了医用聚氯乙烯材料表面肝素的含量,并计算肝素的脱落率.实验表明,在聚氯乙烯表面肝素与聚乙烯亚胺通过阴阳离子相互作用而结合,而且在聚氯乙烯面的肝素含量为944.1μg/cm2,浸泡在生理盐水中700h后,肝素的释放速率先快后慢,最终趋于稳定,其表面肝素脱落量仅为0.78%.这说明聚乙烯亚胺-肝素涂层改性的聚氯乙烯材料具有良好的肝素稳定性与极低的脱落率.
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| 关 键 词： | 抗凝血 脱落率 肝素 |
Modification of polyvinyl chloride with polyethyleneimine-heparin coating and characterization |
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| Authors: | LI Liang WEI Duan-li CAO Nan-nan WANG Yang |
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| Affiliation: | (School of Materials Science and Engineering,Wuhan Institute of Technology, Wuhan 430074,China) |
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| Abstract: | To improve the biological compatibility and antithrombogenicity of polyvinyl chloride （PVC） materials of medical grade,the polyethyleneimine-heparin （PEI-H） coating technique was used to modify the surface of PVC.The stability of heparin coated on the surface of PVC was studied.Fourier transform infrared spectroscope was carried out to characterize the materials.The concentration of coated heparin was calculated and heparin releasing rate was evaluated by toluidine blue spectrophotometry.The results show that heparin and polyethyleneimine can be interacted with each other via the anion-cation interactions;the heparin concentration on PEI-H-coated PVC surface is 944.1 μg/cm2 ;the heparin releasing ratio is only 0.78％ after soaked in saline for 700 hours,which indicates that PEI-H-coated PVC materials have good heparin releasing stability and extremely low heparin releasing ratio. |
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| Keywords: | anticoagulation expulsion rate heparin |
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