| 合并2型糖尿病的乳腺癌患者临床病理特征及预后分析 |
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| 引用本文： | 赵 阳,张 欣,毛国超,闵亦赫,何 蕊,郭爱宁,康华峰,张淑群,闵卫利.合并2型糖尿病的乳腺癌患者临床病理特征及预后分析[J].现代肿瘤医学,2019,0(23):4190-4193. |
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| 作者姓名： | 赵 阳 张 欣 毛国超 闵亦赫 何 蕊 郭爱宁 康华峰 张淑群 闵卫利 |
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| 作者单位： | 1.西安交通大学第二附属医院肿瘤病院，陕西 西安 710004;
2.重庆三峡医药高等专科学校，重庆 404120 |
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| 基金项目： | 陕西省国际科技合作重点项目（编号:2014kw23-07）；西安交通大学第二附属医院院基金青年项目［编号:YJ(QN)201304］ |
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| 摘 要： | 目的:分析合并2型糖尿病乳腺癌患者的临床病理学特征及其与预后的关系。方法:收集西安交通大学第二附属医院肿瘤科2012年1月至2014年12月收治的合并2型糖尿病的乳腺癌患者102例作为糖尿病组，按照1∶2的原则选取同期就诊于西安交通大学第二附属医院肿瘤科的非糖尿病乳腺癌患者204例作为对照组，比较两组临床病理特征以及预后。结果:糖尿病组相比对照组，糖尿病组50岁以上人群比率显著高于对照组（76.5% vs 57.8%，P<0.05），糖尿病组绝经后患者的比率显著高于对照组（69.6% vs 53.9%，P<0.05）；糖尿病组和对照组相比，其中T2期及以上患者所占比例（79.4% vs 66.2%）、淋巴结阳性患者比例（68.6% vs 55.4%）、Ⅱ/Ⅲ期患者所占比例（82.8% vs 67.6%）糖尿病组更高，差异具有统计学意义（P<0.05）。糖尿病组5年复发转移率为14.9%。结论:2型糖尿病是乳腺癌发生发展和淋巴结转移的不良危险因素，乳腺癌合并2型糖尿病患者的病理T分期和临床分期偏晚，淋巴结转移更多，其复发转移率较高，合并2型糖尿病的乳腺癌患者可能预后更差，应更加注重术后定期复查及随访。
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| 关 键 词： | 乳腺癌 2型糖尿病 临床病理特征 预后 |
Clinicopathological features and prognosis of breast cancer patients with type 2 diabetes mellitus |
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| Zhao Yang,Zhang Xin,Mao Guochao,Min Yihe,He Rui,Guo Aining,Kang Huafeng,Zhang Shuqun,Min Weili.Clinicopathological features and prognosis of breast cancer patients with type 2 diabetes mellitus[J].Journal of Modern Oncology,2019,0(23):4190-4193. |
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| Authors: | Zhao Yang Zhang Xin Mao Guochao Min Yihe He Rui Guo Aining Kang Huafeng Zhang Shuqun Min Weili |
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| Affiliation: | 1.Tumor Hospital,Second Affiliated Hospital of Xi'an Jiaotong University，Shaanxi Xi'an 710004，China;2.Chongqing Three Gorges Medical College，Chongqing 404120，China. |
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| Abstract: | Objective:To analyze the clinicopathological characteristics and prognosis of breast cancer complicated with type 2 diabetes mellitus and provide basis for early prevention and individualized treatment of such patients.Methods:Through a case-control study of primary breast cancer patients initially diagnosed from January 2012 to December 2014 in the Affiliated Hospital of Xi'an Jiaotong University，102 cases of the breast cancer patients suffered type 2 diabetes and 204 breast cancer patients without diabetes in the same period were enrolled.Clinicopathological features were compared between the case group and the control group.Results:Compared with the control group，diabetic patients ≥50 years old were higher than those in the control group（76.5% vs 57.8%).The proportion of postmenopausal diabetic patients was higher than that in the control group（69.6% vs 53.9%).The differences were statistically significant（P<0.05).Compared with the control group，there was significant difference in pathological T stage，lymph node metastasis and TNM clinical stage between diabetic group and control group（P<0.05).The 5-year recurrence and metastasis rate was 14.9% in dibetes group.Conclusion:Type 2 diabetes is a poor risk factor for the development of breast cancer and lymph node metastasis.Breast cancer with type 2 diabetes may indicate poor prognosis，should pay more attention to regular postoperative follow-up and follow-up. |
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| Keywords: | breast cancer type 2 diabetes mellitus clinicopathological features prognosis |
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