| 三阴性乳腺癌治疗的研究进展 |
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| 引用本文： | 孙 莉,赵 毅.三阴性乳腺癌治疗的研究进展[J].现代肿瘤医学,2019,0(13):2420-2424. |
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| 作者姓名： | 孙 莉 赵 毅 |
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| 作者单位： | 中国医科大学附属盛京医院第一乳腺外科，辽宁 沈阳 110000 |
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| 基金项目： | 辽宁省自然科学基金（编号:2015020514） |
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| 摘 要： | 三阴性乳腺癌(triple negative breast cancer,TNBC)是雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)及人类表皮生长因子受体(human epidermal growth factor-2,HER-2)均不表达的乳腺癌。按其功能特征可归纳为5类分子分型:以DNA修复缺陷或生长因子为途径的基底细胞样三阴性乳腺癌;以上皮-间充质转化和肿瘤干细胞为特征的间质样三阴性乳腺癌;免疫调节型三阴性乳腺癌;雄激素受体过表达的管腔/分泌型三阴性乳腺癌;HER-2富集型三阴性乳腺癌。三阴性乳腺癌恶性程度高且异型性较大,其治疗困难且预后较差,内分泌治疗及靶向治疗不敏感。目前很多学者对于三阴性乳腺癌的治疗各有研究,并有临床试验证实下述治疗有效。
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| 关 键 词： | 三阴性乳腺癌 治疗 研究进展 |
Research progress in the treatment of triple negative breast cancer |
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| Sun Li,Zhao Yi.Research progress in the treatment of triple negative breast cancer[J].Journal of Modern Oncology,2019,0(13):2420-2424. |
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| Authors: | Sun Li Zhao Yi |
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| Affiliation: | Department of Breast Surgery，Shengjing Hospital of China Medical University，Liaoning Shenyang 110000，China. |
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| Abstract: | Triple negative breast cancer（triple negative breast cancer，TNBC） is the estrogen receptor（ER)，progesterone receptor（PR） and human-epidermal growth factor receptor（HER-2） are not expressed in breast cancer.According to its functional characteristics can be summed up as 5 types of molecular-typing:With DNA repair defects or growth factor pathway of basal cell-like triple negative breast cancer,triple negative breast cancer with the characteristics of a mesenchymal-transformation and tumor stem cells,triple negative breast cancer,androgen receptor-overexpression of lumen/secretory triple-negative breast cancer,human epidermal growth factor 2 receptor（HER-2） enrichment of triple-negative breast cancer.Triple negative breast cancer has a high degree of malignancy and large abnormity，and its treatment is difficult and the prognosis is poor，endocrine therapy and targeted therapy are not sensitive.At present，many scholars have-studied the treatment of triple negative breast cancer，and clinical trials have confirmed that the following treatment are effective. |
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| Keywords: | triple negative breast cancer treatment research progress |
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