| KLF4与S100A14在子宫内膜异位症相关性卵巢癌中的表达及临床意义 |
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| 引用本文： | 王 岩,马宁耶,汤丽红,余 璐,张以薇,焦伊胜.KLF4与S100A14在子宫内膜异位症相关性卵巢癌中的表达及临床意义[J].现代肿瘤医学,2019,0(14):2565-2570. |
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| 作者姓名： | 王 岩 马宁耶 汤丽红 余 璐 张以薇 焦伊胜 |
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| 作者单位： | 中国医科大学附属盛京医院妇产科，辽宁 沈阳 110004 |
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| 基金项目： | National Natural Science Foundation of China(No.81272873）；国家自然科学基金（编号:81272873） |
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| 摘 要： | 目的:探求子宫内膜异位症相关性卵巢癌中Krüppel样因子4(KLF4)与钙离子结合蛋白14(S100A14)的表达情况及临床意义。方法:免疫组化判定KLF4及S100A14分别在36例正常/良性卵巢组织(对照组)、30例卵巢子宫内膜异位症组织(ovarian endometriosis,OE)和49例子宫内膜异位症相关性卵巢癌组织(endometriosis associated ovarian carcinoma,EAOC)中的表达情况,并分析二者与EAOC患者相关临床参数的关系。结果:KLF4在对照组、OE组以及EAOC组中的阳性表达率分别为72.2%(26/36)、63.3%(19/30)、32.7%(16/49),差异有统计学意义(P<0.01)。S100A14在三组中表达的阳性率分别为61.1%(22/36)、63.3%(19/30)、87.8%(43/49),差异有统计学意义(P<0.05)。在EAOC中,KLF4表达与淋巴结转移有显著相关性(P<0.05)。KLF4与S100A14呈负相关(r=-0.138)。结论:KLF4低表达和S100A14高表达可能参与了卵巢子宫内膜异位症恶变,同时KLF4可能促进了EAOC的转移。
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| 关 键 词： | KLF4 S100A14 子宫内膜异位症相关性卵巢癌 |
Expression and clinical significance of KLF4 and S100A14 in endometriosis associated ovarian carcinoma |
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| Wang Yan,Ma Ningye,Tang Lihong,Yu Lu,Zhang Yiwei,Jiao Yisheng.Expression and clinical significance of KLF4 and S100A14 in endometriosis associated ovarian carcinoma[J].Journal of Modern Oncology,2019,0(14):2565-2570. |
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| Authors: | Wang Yan Ma Ningye Tang Lihong Yu Lu Zhang Yiwei Jiao Yisheng |
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| Affiliation: | Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China. |
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| Abstract: | Objective:To investigate the expression and clinical significance of Krüppel-like factor 4 (KLF4) and calcium ion-binding protein 14 (S100A14) in endometriosis associated ovarian carcinoma.Methods:To detect the expression of KLF4,S100A14 in 36 cases of normal/benign ovarian tissues (control group),30 ovarian endometriosis (OE) cases and 49 cases of endometriosis associated ovarian carcinoma(EAOC),analyze the relationship between them and clinical parameters in EAOC by immunohistochemistry.Results:The positive rates of KLF4 in the control group,OE and EAOC were 72.2%(26/36),63.3%(19/30) and 32.7%(16/49),respectively.The difference was statistically significant(P＜0.01).The positive rates of S100A14 in the three groups were 61.1%(22/36),63.3%(19/30),and 87.8%(43/49),respectively(P＜0.05).In EAOC,KLF4 expression was significantly correlated with lymph node metastasis(P＜0.05).KLF4 was negatively correlated with S100A14 (r=-0.138).Conclusion:Low expression of KLF4 and high expression of S100A14 may be involved in the development of malignant transformation of ovarian endometriosis,and KLF4 may promote the metastasis of EAOC. |
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| Keywords: | KLF4 S100A14 endometriosis associated ovarian carcinoma |
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