| D2-40标记食管鳞癌淋巴管浸润的检测及其临床病理意义 |
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| 引用本文： | 白冰,马伟,王凯,哈斯塔,王建波,谭炳煦,王娜娜,杨圣思,贾亦斌,程玉峰.D2-40标记食管鳞癌淋巴管浸润的检测及其临床病理意义[J].中国肿瘤临床,2013,0(9):543-546. |
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| 作者姓名： | 白冰 马伟 王凯 哈斯塔 王建波 谭炳煦 王娜娜 杨圣思 贾亦斌 程玉峰 |
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| 作者单位： | ①.山东大学齐鲁医院放疗科（济南市 250012） |
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| 基金项目： | 山东省科技发展计划项目基金2012GGE27088中国博士后科学基金2011M500531 |
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| 摘 要： | 目的 探讨D2-40标记食管鳞癌淋巴管浸润(LVI)的临床病理意义。 方法 应用免疫组织化学S-P法检测107例食管鳞癌D2-40蛋白表达并观察淋巴管受肿瘤细胞浸润的情况, 分析其与食管鳞癌临床病理因素之间的关系, 观察患者总生存期。 结果 食管鳞癌组织LVI阳性组淋巴结转移率70%, LVI阴性组淋巴结转移率21%, LVI阳性组转移率高于阴性组, 多因素分析显示两组间差异有统计学意义(P < 0.001)。LVI阳性组中位生存时间为26个月, LVI阴性组中位生存时间43个月, 单因素分析显示两组间差异有统计学意义(P=0.014), 多因素分析显示LVI不能成为食管鳞癌术后患者预后的独立危险因素(P=0.062), 淋巴转移(P=0.031)、临床分期(P=0.019)和肿瘤残留(P=0.026)是预后的独立危险因素。 结论 D2-40标记的LVI可以预测食管鳞癌患者的淋巴结转移。
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| 关 键 词： | 食管鳞癌 淋巴管浸润 D2-40 淋巴结转移 预后 |
| 收稿时间： | 2012-09-29 |
Detection of D2-40 monoclonal antibody-labeled lymphatic vessel invasion in esophageal squamous cell carcinoma and its clinicopathologic significance |
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| Affiliation: | ①.Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012②.Department of Oncology, Wendeng Central Hospital, Weihai 264400, China③.Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 8600862, Japan |
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| Abstract: | Objective This study aims to investigate the clinicopathological significance of lymphatic vessel invasion(LVI) labeled by D2-40 monoclonal antibody in esophageal squamous cell carcinoma(ESCC). Methods Immunohistochemical assay was used to detect the expression of D2-40 and LVI in 107 ESCC cases.Then, the correlation between the clinicopathological feature and the overall survival time in patients was analyzed. Results The lymph node metastasis rates were 70% and 21% in the LVI-positive and LVI-negative groups, respectively.The nodal metastasis rate was higher in the LVI-positive group than in the LVI-negative group.Multivariate regression analyses showed that LVI was related to nodal metastasis(P < 0.001).The median survival times of the patients were 26 and 43 months in the LVI-positive and LVI-negative groups, respectively.Although the univariate regression analysis showed significant difference between the two groups(P=0.014), the multivariate regression analyses revealed that LVI was not an independent prognostic factor for overall survival in the ESCC patients(P=0.062).Lymphatic node metastasis(P=0.031), clinical stage(P=0.019), and residual tumor(P=0.026) were the independent prognostic factors. Conclusion LVI labeled by D2-40 monoclonal antibody is a risk factor predictive of lymph node metastasis in ESCC patients. |
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| Keywords: | esophageal squamous cell carcinoma lymphatic vessel invasion D2-40 lymph node metastasis prognosis |
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