| 胃癌干细胞与微环境的研究进展 |
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| 引用本文： | 高晨.胃癌干细胞与微环境的研究进展[J].肿瘤研究与临床,2011,23(1):68-70. |
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| 作者姓名： | 高晨 |
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| 作者单位： | 兰州大学第一医院肿瘤外科,730000 |
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| 基金项目： | 教育部长江学者讲座教授项目，教育部新世纪优秀人才支持计划 |
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| 摘 要： | 胃癌目前是仅次于肺癌的第二大致死性肿瘤，目前胃癌的发病机制还不是很清楚。近年来随着对肿瘤干细胞（CSC）和肿瘤生物学的研究，目前已经在多种实体瘤中发现CSC，但是由于胃癌干细胞缺乏特异性的标志物，因此还有很多空白待探究。虽然已发现一些胃癌干细胞表面标志物如CD44、CD133等，但缺乏特异性，仍需进一步探究更具特异性的胃癌干细胞标志物。CSC生存的环境在肿瘤的进程中也起重要的作用。文章对胃癌干细胞和微环境进行研究将有助于胃癌的诊断和治疗。
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| 关 键 词： | 胃肿瘤 肿瘤干细胞 微环境 |
Research progress of gastric cancer stem cells and microenvironment |
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| GAO Chen.Research progress of gastric cancer stem cells and microenvironment[J].Cancer Research and Clinic,2011,23(1):68-70. |
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| Authors: | GAO Chen |
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| Affiliation: | GAO Chen, GUAN Quan-lin,ZHA NG Ying, ZHU Bing-dong. Department of Oncological Surgery, the First Hospital of Lanzhou UniVersity, Lanzhou 730000,China |
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| Abstract: | Cancer stem cells (CSC) have been defined as an unique subpopulation in tumors that possess the ability to initiate tumor growth and sustain tumor self-renewal. The tumor stem cell model proposes that tumor stem cells are the origin of most tumors. Accompanying with further extension in the investigation of cancer stem cells, the effects of niche that serves as'their microenvironment in tissue on the functions of cancer stem cells attract more and more attention, which plays important roles in maintaining the characteristics of cancer stem cells. It is essential to understand how cancer stem cells interact with their microenvironment. Although the evidence has been provided to support the existence of CSCs in various solid tumors, the identity of gastric CSCs has not been reported. In this review, we will examine gastric cancer stem cell niches and their impact on stem cell biology. The research on gastric cancer stem cell will provide new approaches for improved understanding of gastric cancer biology and gastric cancer treatment. |
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| Keywords: | Stomach neoplasms Tumor stem cells Niche |
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