| 陕西省汉中地区妇女人群HPV感染状况及不同年龄段亚型分布特征 |
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| 引用本文： | 李军,何宝明,南星,王一羽,王国庆,田小飞,阎涛,付玉兰,柳瑛,尹悦,原荣.陕西省汉中地区妇女人群HPV感染状况及不同年龄段亚型分布特征[J].中华疾病控制杂志,2017,21(7):718-722. |
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| 作者姓名： | 李军 何宝明 南星 王一羽 王国庆 田小飞 阎涛 付玉兰 柳瑛 尹悦 原荣 |
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| 作者单位： | 1. 西安交通大学医学院附属陕西省肿瘤医院基础研究中心, 陕西 西安 710061; |
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| 基金项目： | 陕西省科技计划发展项目资助 |
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| 摘 要： | 目的 探讨陕西省汉中地区妇女人群人乳头瘤病毒（human papillomavirus，HPV）亚型分布特征。方法 采用聚合酶链反应（polymerase chain reaction，PCR）反向点杂交法对HPV感染进行分型检测。结果 汉中地区妇女人群HPV感染率为29.86%，高危、低危、高低危感染率分别为26.79%、1.57%和1.49%。高危单一和多重感染分别占总人群的21.08%和5.71%。在≤ 20岁和>60岁年龄组均有较高感染率，在>21岁各组中随年龄增长感染率逐步升高。高危型感染率在51~岁年龄组为最高。总体和单一常见亚型为16、58、52、53、33、39型，分别占总体感染73.25%和79.71%，16亚型分别占27.11%和34.41%；多重常见亚型为16、52、58、53、39和33型，占多重感染的64.75%，16亚型占17.51%。单一占总感染的75.66%，高危单一占70.59%；多重占总感染的24.34%，高危多重占24.13%。在多重感染中以二重高危感染最为多见，占多重感染的72.50%。结论 汉中地区妇女人群HPV感染率较高，其常见高危亚型为16，58，52，53，33，39型，低危型为6和43型。不同年龄段的亚型分布各有不同。HPV总体感染、高危、低危和高低危混合感染率在不同年龄段均有差异。
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| 关 键 词： | 人乳头瘤病毒 子宫颈 感染 基因 陕西 |
| 收稿时间： | 2016-12-20 |
Investigation on HPV infection status and subtype distribution in women of different ages in Hanzhong area of Shanxi Province |
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| LI Jun,HE Bao-ming,NAN Xing,WANG Yi-yu,WANG Guo-qing,TIAN Xiao-fei,YAN Tao,FU Yu-lan,LIU Ying,YIN Yue,YUAN Rong.Investigation on HPV infection status and subtype distribution in women of different ages in Hanzhong area of Shanxi Province[J].Chinese Journal of Disease Control & Prevention,2017,21(7):718-722. |
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| Authors: | LI Jun HE Bao-ming NAN Xing WANG Yi-yu WANG Guo-qing TIAN Xiao-fei YAN Tao FU Yu-lan LIU Ying YIN Yue YUAN Rong |
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| Affiliation: | 1. Basic Research Center, Shanxi Provincial Tumor Hospital, Xi'an Jiaotong University, Xi'an 710061, China;2. Clinical Laboratory, Hanzhong Central Hospital of Shanxi Province, Hanzhong 723000, China;3. Gynecologic Oncology Center, Shanxi Provincial Tumor Hospital, Xi'an Jiaotong University, Xi'an 710061, China |
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| Abstract: | Objective To investigate infection status and distribution of different types of human papillomavirus (HPV) in women of different ages in Hanzhong area of Shanxi Province.Methods Twenty-three HPV genotypes were analyzed by PCR and reverse dot blot hybridization technique.Results The total infection rate,high-risk HPV infection rate,low-risk HPV infection rate and mixed high and low risk infection rate were 29.86％,26.79％,1.57％ and 1.49％ respectively.The infection rate of single high-risk subtype of HPV and multiple subtype of HPV were 21.08％ and 5.71％ respectively.HPV infection rate was higher for women under 20 years old and over 60 years old groups and the infection rate gradually increased along with women's age in above 21 years old age groups.High-risk HPV subtype infection rate was the highest in 50-years old group.The most common subtype were 16,58,52,53,33 and 39 in total and single subtype infection and its infection rates were 73.25％ and 79.71％ in HPV infection respectively and subtype 16 reached 27.11％ and 34.41％ in all HPV infection respectively.Single and high-risk single type infection rates were 75.66％ and 70.59％ in total HPV infection respectively.Multiple and high-risk multiple infection rates were 24.34％ and 24.13％ in total infection respectively.Conclusions The HPV infection rate of women in Hanzhong region of Shanxi province is higher especially in the over 60 years old age group and the most common HPV high and low risk subtypes are 16,58,52,53,33,39 and 6,43.The infection rates of total,high-risk,low-risk and high-low-risk were significantly different in different age groups. |
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| Keywords: | Human papillomavirus Cervical Infection Gene Shanxi Province |
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