| 血清同型半胱氨酸、脂蛋白(a)和超敏C反应蛋白联合检测对脑梗死患者的临床意义 |
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| 作者单位： | 首都医科大学附属北京潞河医院检验科, 北京 101101 |
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| 摘 要： | 目的 探讨脑梗死患者血清同型半胱氨酸(homocysteine,HCY)、脂蛋白(a)lipoprotein(a), Lp(a)]和超敏C-反应蛋白(high sensitive C-reactive protein, hs-CRP)的变化及联合检测的临床意义。方法 选取183例脑梗死患者和同期健康体检者163例,分别检测样本中同型半胱氨酸、脂蛋白(a)和超敏C-反应蛋白,并进行统计学分析。使用ROC曲线确定此3项结果诊断脑梗死的界值。结果 脑梗死组HCY、Lp(a)和hs-CRP分别为(16.7±6.3) μmol/L、(343.6±150.1)mg/L、(3.87±1.88)mg/L,正常对照组分别为(12.9±4.7) μmol/L、(205.4±190)mg/L、(2.45±0.69)mg/L。脑梗死组的3项检测指标均明显高于正常对照组,差异有统计学意义(P<0.05)。结论 脑梗死的发生与HCY、Lp(a)和hs-CRP密切相关,可作为其危险因素。
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| 关 键 词： | 脑梗死 同型半胱氨酸 脂蛋白(a) 超敏C-反应蛋白 联合检测 |
| 收稿时间： | 2015-04-21 |
Clinical significance of joint detection of serum homocysteine,lipoprotein(a) and high sensitive C-reactive protein in cerebral infarction |
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| Authors: | Wang liqiu Yin changbin Li jiawei |
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| Affiliation: | Department of Clinical Labs, Beijing Luhe Hospital, Capital Medical University, Beijing 101101, China |
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| Abstract: | Objective To investigate the changes and the clinical significance of joint detection of serum homocysteine (HCY), lipoprotein(a)Lp(a)] and high sensitive C-reactive protein (hs-CRP) in patients with cerebral infarction. The cut of value of three results of the patients with cerebral infarction was determined by ROC curve. Methods The levels of HCY, Lp(a),hs-CRP were measured in 183 patients with cerebral infarction and 163 healthy controls and the results were made statistical analysis. Results The levels of Hcy,Lp(a) and hs-CRP in patients with cerebral infarction were (16.7±6.3) μmol/L, (343.6±150.1)mg/L, (3.87±1.88)mg/L, in healthy control group were (12.9±4.7) μmol/L, (205.4±190)mg/L,(2.45±0.69)mg/L. The levels of Hcy,Lp(a) and hs-CRP in patients with cerebral infarction were significantly higher than those in healthy controls(P<0.05).Conclusion Occurrence of cerebral infarction and Hcy, Lp(a) and hs-CRP levels were closely correlated,so the indexes can be used as risk factors. |
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| Keywords: | cerebral infarction homocysteine lipoprotein(a) high sensitive C-reactive protein joint detection |
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