| 汽化过氧化氢应用于烧伤重症监护病房终末消毒的效果研究 |
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| 引用本文： | 张寅,唐毅,王亦晨,叶震遐,汪雯靓,刘怡青,滕培敏,张祎博,王群,糜琛蓉.汽化过氧化氢应用于烧伤重症监护病房终末消毒的效果研究[J].中国感染控制杂志,2019,18(9):830-834. |
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| 作者姓名： | 张寅 唐毅 王亦晨 叶震遐 汪雯靓 刘怡青 滕培敏 张祎博 王群 糜琛蓉 |
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| 作者单位： | 汽化过氧化氢应用于烧伤重症监护病房终末消毒的效果研究 |
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| 基金项目： | 上海交通大学医学院科技基金项目（jyhz1812）；上海市黄浦区医疗卫生重点研究发展项目（HWZFX201807）；国家卫生计生委医药卫生科技发展研究中心课题（2017ZX01001S1-04） |
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| 摘 要： | 目的运用汽化过氧化氢消毒法对烧伤重症监护病房进行终末消毒,比较不同消毒用量的消毒效果。方法选取某院灼伤整形科一间110 m3空病房作为试验场地。将枯草杆菌黑色变种芽孢菌片打开后放置于事先预定无遮隔的15个布点位置(距消毒机器0、1、2、3、4 m处,每处再分上、中、下3个平面),以及无盖无菌试管内15个布点(位置同前),每个位点无盖无菌试管内和无遮隔各放置一张过氧化氢指示胶带。根据病房的大小分别以8、12 g/m3计算过氧化氢用量。待消毒5 h后,观察化学指示胶带变色情况,菌片放入肉汤培养,培养后观察结果。应用SPSS 20.0统计软件进行数据分析。结果采用8 g/m3过氧化氢消毒时,峰值浓度为255.9 g,达到峰值浓度的时间为1 h 48 min;采用12 g/m3消毒时,峰值浓度为337.6 g,达到峰值浓度的时间为2 h 26 min。当两种消毒用量消毒时间达到8 h,病房内的浓度基本相同。无遮隔情况下,两种消毒用量化学指示胶带均变色;无盖无菌试管内的化学指示胶带不能完全变色。过氧化氢消毒用量分别为8、12 g/m3时,无遮隔的标本阳性率分别为6.67%和2.67%,差异无统计学意义(P0.05),且各位点不同消毒用量的消毒效果比较,差异均无统计学意义(均P0.05)。结论化学指示胶带变色在临床中可作为消毒效果的初步判断。使用汽化过氧化氢进行终末消毒时要尽可能地充分暴露需消毒的物品,根据实际情况确定消毒时间和消毒用量,病室内不同位点消毒效果基本相同。
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| 关 键 词： | 汽化过氧化氢 消毒 烧伤科 重症监护病房 |
| 收稿时间： | 2019-08-15 |
Effect of hydrogen peroxide vapor on terminal disinfection in burn intensive care unit |
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| ZHANG Yin,TANG Yi,WANG Yi-chen,YE Zhen-xi,WANG Wen-liang,LIU Yi-qing,TENG Pei-min,ZHANG Yi-bo,WANG Qun,MI Chen-rong.Effect of hydrogen peroxide vapor on terminal disinfection in burn intensive care unit[J].Chinese Journal of Infection Control,2019,18(9):830-834. |
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| Authors: | ZHANG Yin TANG Yi WANG Yi-chen YE Zhen-xi WANG Wen-liang LIU Yi-qing TENG Pei-min ZHANG Yi-bo WANG Qun MI Chen-rong |
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| Affiliation: | 1. Department of Burn Plastic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China;2. Department of Disinfection and Infection Control, Shanghai Huangpu Center for Disease Control and Prevention, Shanghai 200023, China;3. Department of Healthcare-associated Infection Management, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China |
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| Abstract: | Objective To compare the terminal disinfection effect of different dosage of hydrogen peroxide vapor (HPV) on burn intensive care unit(BICU). Methods A 110 m3 empty ward in department of burn and plastic surgery of a hospital was selected as the test location. Bacillus subtilis var. niger spore tablets were placed at 15 points without shielding (0, 1, 2, 3, 4 m away from the disinfector, each point was divided into upper, middle and lower planes) and 15 points (same position) in the uncovered sterile test tube, hydrogen peroxide indicator tape was placed at each point of uncovered sterile test tube and non-shielding point. The amount of hydrogen peroxide was calculated according to the size of ward (8 g/m3 and 12 g/m3, respectively). After 5 hours of disinfection, change in color of chemical indicator tape was observed, spore tablets were placed in broth culture tube, result was observed after culture. Data was analyzed using SPSS 20.0 statistical software. Results When 8 g/m3 hydrogen pero-xide was used for disinfection, the peak concentration was 255.9 g, the time to reach peak concentration was 1 hour and 48 minutes; when 12 g/m3 hydrogen peroxide was used for disinfection, the peak concentration was 337.6 g, the time to reach peak concentration was 2 hour and 26 minutes. When disinfection time of two disinfection dosages reached 8 hours, the concentration of ward was basically the same. Under the condition of non-shielding, chemical indicator tape of two kinds of disinfection dosage all changed color, but could not completely change color in uncovered sterile test tube. When disinfection dosage of hydrogen peroxide was 8 g/m3 and 12 g/m3, positive rates of the non-shielding specimens were 6.67% and 2.67% respectively, with no significant difference (P>0.05), and disinfection effect was not significantly different among different points (all P>0.05). Conclusion Change in color of chemical indicator tape can be used as a preliminary evaluation of disinfection effect in clinic. When using HPV for terminal disinfection, it is necessary to expose the items as far as possible, disinfection time and dosage should be determined according to the actual situation, disinfection effect of different points in the ward is basically the same. |
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| Keywords: | hydrogen peroxide vapor disinfection burn unit intensive care unit |
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