Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis |
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| Authors: | Ruijgrok Elisabeth J Fens Marcel H A M Bakker-Woudenberg Irma A J M van Etten Els W M Vulto Arnold G |
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| Affiliation: | Department of Clinical Pharmacy, Medical Center Rijnmond-Zuid, Olympiaweg 350, 3078 HT Rotterdam, The Netherlands. e.j.ruijgrok@hetnet.nl |
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| Abstract: | Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls. |
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