| 慢性牙周炎患者唾液中 miR-1246的表达及其临床意义 |
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| 引用本文： | 姚伟莉,袁静,耿彪,王丽丽,韩明明.慢性牙周炎患者唾液中 miR-1246的表达及其临床意义[J].现代检验医学杂志,2021,0(1):65-67. |
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| 作者姓名： | 姚伟莉 袁静 耿彪 王丽丽 韩明明 |
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| 作者单位： | （保定市第二中心医院检验科，河北涿州 072750） |
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| 摘 要： | 目的 探讨慢性牙周炎（ CP）患者唾液中 miR-1246的表达及其临床意义。方法 选取 2017年 1月 ~2019年 5月保定市第二中心医院收治的 94例 CP患者作为 CP组和 50例体检正常者作为对照组。 CP患者分为轻度牙周炎组（n=23），中度牙周炎组（ n=37）和重度牙周炎组（ n=35），检测各组唾液中 miR-1246的表达水平。对 CP患者进行牙周基础治疗，分别检测治疗前和治疗 6周后患者唾液中 miR-1246的表达水平，并检查牙周探诊深度 (PD)，附着丧失 (AL)，菌斑指数 (PLI) 和出血指数（ BI）各项牙周临床指标。采用 Pearson相关分析 CP患者 miR-1246表达水平与 PD，AL， PLI及 BI的相关性。结果 CP组唾液中 miR-1246表达水平明显高于对照组（ 7.28±2.56 vs 3.52±1.14），差异有统计学意义（ t=16.294，均 P<0.01）。重度组唾液中 miR-1246表达水平均明显高于中度组和轻度组（ 10.47±3.38 vs 7.38±2.70, 4.24±1.30），差异有统计学意义（ t=13.516，21.482，P<0.01）。CP患者治疗后唾液中 miR-1246表达水平明显低于治疗前（ 4.75±1.61 vs 7.28±2.56），差异有统计学意义（t=10.490，P<0.01）。CP患者治疗后 PD（2.84±0.72mm vs 5.16±1.30 mm），AL（3.08±0.64mm vs 5.62±1.15 mm），PLI（1.13±0.28 vs 2.62±0.41）及 BI（2.95±0.58 vs 1.64±0.47）均明显低于治疗前，差异均有统计学意义（ t=8.742~10.873，均 P<0.01）。相关分析显示，治疗前后 CP患者 miR-1246表达水平与 PD，AL，PLI及 BI均呈正相关（ r=0.592~0.874，均 P<0.01）。结论 CP患者唾液中 miR-1246表达水平明显升高，治疗后明显下降，其表达水平与 CP严重程度和牙周炎临床指标密切相关，有望为 CP的防治提供新的思路。
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| 关 键 词： | 慢性牙周炎 miR-1246 |
Expression of miR-1246 in Saliva of Patients with Chronic Periodontitis and Its Clinical Significance |
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| YAO Wei-li,YUAN Jing,GENG Biao,WANG Li-li,HAN Mingming.Expression of miR-1246 in Saliva of Patients with Chronic Periodontitis and Its Clinical Significance[J].Journal of Modern Laboratory Medicine,2021,0(1):65-67. |
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| Authors: | YAO Wei-li YUAN Jing GENG Biao WANG Li-li HAN Mingming |
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| Affiliation: | （Department of Clinical Laboratory，the Second Central Hospital of Baoding, Hebei Zhuozhou 072750，China） |
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| Abstract: | Objective To investigate the expression of miR-1246 in saliva of patients with chronic periodontitis(CP)and its clinical significance.Methods 94 CP patients admitted to the Second Central Hospital of Baoding City from January 2017 to May 2019 were selected as the CP group and 50 normal patients as the control group.Patients with CP were divided into mild periodontitis group(n=23),moderate periodontitis group(n=37)and severe periodontitis group(n=35).The expression level of miR-1246 in saliva of each group was detected.The CP patients were treated with periodontal basic therapy,and the expression level of miR-1246 in saliva of the patients before and after treatment was detected respectively,and the periodontal clinical indicators of depth of exploration(PD),loss of attachment(AL),plaque index(PLI)and bleeding index(BI)were examined.Pearson correlation were used to analyze the correlation between the expression of miR-1246 and PD,AL,PLI and BI in patients with CP.Results The expression level of miR-1246 in saliva of CP group was significantly higher than that of control group(7.28±2.56 vs 3.52±1.14,t=16.294,P<0.01).The expression level of miR-1246 in saliva of severe group(10.47±3.38 vs 7.38±2.70,4.24±1.30)were significantly higher than that of moderate group and mild group,the difference was statistically significant(t=13.516,21.482,all P<0.01).The expression level of miR-1246 in saliva of CP patients after treatment(4.75±1.61 vs 7.28±2.56)was significantly lower than that before treatment,the difference was statistically significant(t=10.490,P<0.01).After treatment,PD(2.84±0.72mm vs 5.16±1.30 mm),AL(3.08±0.64mm vs 5.62±1.15 mm),PLI(1.13±0.28 vs 2.62±0.41)and BI(2.95±0.58 vs 1.64±0.47)in CP patients were significantly lower than those before treatment,the difference was statistically significant(r=8.742~10.873,all P<0.01).The correlation analysis showed that the expression level of miR-1246 was positively correlated with PD,AL,PLI and BI in CP patients before and after treatment(r=0.592~0.874,all P<0.01).Conclusion The expression level of miR-1246 in the saliva of CP patients was significantly increased and decreased significantly after treatment.The expression level of miR-1246 was closely related to the severity of CP and clinical indicators of periodontitis,which was expected to provide a new idea for the prevention and treatment of CP. |
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| Keywords: | chronic periodontitis miR-1246 |
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