| 静息态功能磁共振成像分析原发性失眠患者大脑的小世界网络 |
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| 引用本文： | 黄伟康,李志铭,吴水天,洪静静,文 戈.静息态功能磁共振成像分析原发性失眠患者大脑的小世界网络[J].南方医科大学学报,2021,41(3):424-429. |
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| 作者姓名： | 黄伟康 李志铭 吴水天 洪静静 文 戈 |
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| 作者单位： | 南方医科大学南方医院增城分院(增城区中心医院),广东 广州 511340;广州医科大学第二附属医院,广东广州 510260 |
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| 基金项目： | 广东省医学科学技术研究项目 |
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| 摘 要： |
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| 关 键 词： | 静息态功能磁共振成像 原发性失眠 小世界网络 |
Small-world network of patients with primary insomnia: a resting-state functional magnetic resonance imaging study |
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| ì ÿë, ýí,&#x; &#x;,Ú &#x;&#x;,&#x; &#x;.Small-world network of patients with primary insomnia: a resting-state functional magnetic resonance imaging study[J].Journal of Southern Medical University,2021,41(3):424-429. |
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| Authors: | ì ÿë ýí &#x; &#x; Ú &#x;&#x; &#x; &#x; |
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| Abstract: | Objective To explore the changes of small-world network properties in patients with primary insomnia based on
resting-state functional magnetic resonance imaging (rs-fMRI). Methods The rs-MRI data and neurological scale data of 65 patients and 60 matched healthy controls were collected. The brain network was constructed using GRENTA software. SPSS software and network-based statistical analysis methods were used for statistical analysis. Results There was no significant difference between the two groups in terms of age, gender or education level (P>0.05), but PSQI, HAMA and HAMD scale scores differed significantly between the two groups (P<0.05). Both of the groups showed attributes of the small-world network. Compared with the control group, the patients with insomnia showed lower Cp, γ, Eloc, λ, connectivity, and σ of the small world network (P<0.05). Conclusion Patients with primary insomnia have lower global and local efficiencies than healthy individuals, and their ability to transmit information on the surface topology is impaired. Our data provide objective imaging evidences for the neuropathological mechanism of patients with primary insomnia. |
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| Keywords: | 静息态功能磁共振成像 原发性失眠 小世界网络 |
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