| 环状RNA circ-0014359在胶质瘤组织中的表达及意义 |
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| 引用本文： | 徐敬轩,杨,岩,张,勖,郭,正,喀斯木,栾新平.环状RNA circ-0014359在胶质瘤组织中的表达及意义[J].中国临床神经外科杂志,2020,0(10):680-682. |
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| 作者姓名： | 徐敬轩 杨 岩 张 勖 郭 正 喀斯木 栾新平 |
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| 作者单位： | 830028 乌鲁木齐，新疆医科大学第二附属医院神经外科（徐敬轩、杨 岩、张 勖、郭 正、喀斯木、栾新平） |
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| 摘 要： | 目的 探讨环状RNA circ-0014359（简称circ-0014359）在胶质瘤组织中的表达及意义。方法 实时定量PCR法检测118例胶质瘤组织和60例正常脑组织circ-0014359的表达水平。以circ-0014359表达量中位数为截断值，分为高表达和低表达。随访结束时间为2019年6月，总生存期（OS）为术后第1天至死亡或最后一次随访，无进展生存期（PFS）为术后至第一次发生疾病进展或任何原因死亡的时间。结果 胶质瘤组织circ-0014359表达水平明显高于正常脑组织（P<0.05）。随胶质瘤病理级别增高，circ-0014359表达水平明显增高（P<0.05）。多因素Cox比例回归风险模型分析结果显示，circ-0014359高表达是胶质瘤病人OS和PFS较短的独立影响因素（P<0.05）。生存曲线分析显示，高表达组OS和PFS分别为（25.31±8.03）个月和（15.22±3.13）个月]明显低于低表达组分别为（35.19±7.03）个月和（19.32±2.84）个月；P<0.05]。结论 胶质瘤组织circ-0014359呈高表达，并且与不良预后有关。
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| 关 键 词： | 胶质瘤 环状RNA circ-0014359 预后 |
Expression of circRNA circ-0014359 in human glioma tissues and its clinical significance |
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| XU Jing-xuan,YANG Yan,ZHANG Xu,GUO Zheng,Kasmu,LUAN Xin-ping..Expression of circRNA circ-0014359 in human glioma tissues and its clinical significance[J].Chinese Journal of Clinical Neurosurgery,2020,0(10):680-682. |
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| Authors: | XU Jing-xuan YANG Yan ZHANG Xu GUO Zheng Kasmu LUAN Xin-ping |
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| Affiliation: | Department of Neurosurgery, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China |
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| Abstract: | Objective To investigate the expression of circRNA circ-0014359 in human glioma tissues and its clinical significance. Methods The expressions of circRNA circ-0014359 were detected in glioma tissues obtained from 118 patients with glioma and in normal brain tissues obtained from 60 patients with traumatic brain injury by real-time quantitative PCR. With the median expression lvele of circRNA circ-0014359 as the cutoff value, the glioma patients were divided into high expression group and low expression group. The end of follow-up time was June 2019. The overall survival (OS) was from the first day after surgery to death or the last follow-up. The progression-free survival (PFS) was from the first postoperative disease progression or death from any cause. Results The expression level of circRNA circ-0014359 in glioma tissues was significantly higher than that in normal brain tissues (P<0.05). The expression level of circRNA circ-0014359 in low-grade glioma tissues was significantly lower than that in high-graode glioma tissues (P<0.05). The analysis of multivariate Cox proportional regression risk model showed that the high expression of circRNA circ-0014359 was an independent risk factor of shorter OS and PFS in glioma patients (P<0.05). Survival curve analysis showed that OS and PFS in the high expression group (25.31±8.03) months and (15.22±3.13) months, respectively] were significantly shorter than those in the low expression group (35.19±7.03) months and (19.32±2.84) months, respectively; P<0.05]. Conclusion CircRNA circ-0014359 is highly expressed in glioma tissue and is related to poor prognosis of patients with glioma. |
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| Keywords: | Glioma Circular RNA circ-0014359 Prognosis |
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