| 粘着斑激酶在前列腺癌中表达的研究 |
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| 引用本文： | 廖洪利,米叶赛尔·阿不都拉.粘着斑激酶在前列腺癌中表达的研究[J].现代检验医学杂志,2016,0(5):132-133. |
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| 作者姓名： | 廖洪利 米叶赛尔·阿不都拉 |
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| 作者单位： | 新疆喀什地区第一人民医院检验科,新疆喀什 844000 |
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| 摘 要： | 目的 探讨粘着斑激酶(FAK)表达与前列腺癌发病的关系。方法 前列腺癌患者60例,经手术切除的癌组织及相应的癌旁组织行免疫组化检测FAK表达情况。Trizol法提取组织总RNA,RT-PCR检测FAK mRNA表达量,并进行统计学分析。结果 FAK在60例前列腺癌组织中表达明显比癌旁组织高,两者差异有统计学意义(χ2=72.55,P<0.01),FAK的mRNA水平在前列腺癌组织表达显著比癌旁组织高(t=30.51,P<0.01)。淋巴结转移情况看pN0M0表达阳性例数比pN3M1少,pN0M0的mRNA表达量比pN3M1的表达量低,差异有统计学意义(t=25.43,P<0.01)。结论 前列腺癌细胞FAK表达与侵袭转移相关。
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| 关 键 词： | 前列腺癌 粘着斑激酶(FAK) 免疫组化 |
Research on Expression of FAK in Prostate Carcinoma |
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| LIAO Hong-li,MIYESAIER·Abdula.Research on Expression of FAK in Prostate Carcinoma[J].Journal of Modern Laboratory Medicine,2016,0(5):132-133. |
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| Authors: | LIAO Hong-li MIYESAIER·Abdula |
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| Affiliation: | Departmentof Clinical Laboratory,
the First People Hospital of Kashi,Xinjiang Kashi 844000,China |
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| Abstract: | Objective To investigate the relationships between expression of FAK and Prostate Carcinoma(PC)morbidity.MethodsBy surgery,get cancer tissue and para-carcinama tissue from 60 cases PC.To detect FAK expression by immunohistochemical.To extract total RNA byTrizol.To detect the FAK mRNA by RT-PCR,and analysis these data.Results FAK expression level in cancer tissue was higher than that in para-carcinama tissue.There was statistical difference between them(χ2=72.55,P<0.01).mRNA expression levels of FAK in cancer tissue showed significant higher than the levels in para-carcinama tissue(t=30.51,P<0.01).According to lymphatic metastasis,the expression positive cases of FAK in pN0M0 classification were lower than these in pN3M1 classification,and mRNA expression levels of FAK were the same results.There were clearly statistical distinctive(t=25.43,P<0.01).Conclusion The expression of FAK in PC cells was associated with tumor invasion. |
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