| 血清中PGⅠ、PGⅡ及G-17检测在胃癌早期诊断中的应用 |
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| 引用本文： | 刘 冰,杨 帅,陈 辉.血清中PGⅠ、PGⅡ及G-17检测在胃癌早期诊断中的应用[J].医学信息,2019,0(22):162-163. |
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| 作者姓名： | 刘 冰 杨 帅 陈 辉 |
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| 作者单位： | （1.天津市宝坻区人民医院生化科，天津 301800；2.天津市宝坻区人民医院免疫科，天津 301800；3.天津市宝坻区妇产医院检验科，天津 301800） |
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| 摘 要： | 目的 研究血清中胃蛋白酶原Ⅰ（PGⅠ）、胃蛋白酶原Ⅱ（PGⅡ）及胃泌素-17（G-17）检测在胃癌早期诊断中的应用价值。方法 选择2017年1月~2019年1月本院收治的胃病患者98例，其中胃癌患者48例设为观察A组，萎缩性胃炎患者50例设为观察B组，另选取同期体检健康者50例设为对照组，分别行PGⅠ、PGⅡ及G-17检测，并以胃镜或手术结果为对照，分析PGⅠ、PGR（PGⅠ/PGⅡ）及G-17单项及联合诊断结果。结果 PGⅠ、PGR及G-17联合诊断的准确度高于单项检测，差异有统计学意义（P＜0.05）；联合诊断敏感性高于PGR、G-17单项检测，差异有统计学意义（P＜0.05）；对照组、观察B组、观察A组PGⅠ、PGR依次下降，PGⅡ依次升高，差异有统计学意义（P＜0.05）；观察A组G-17高于观察B组，差异有统计学意义（P＜0.05）。结论 血清中PGⅠ、PGⅡ及G-17单项检测在胃癌早期诊断中均具有一定价值，但联合检测可进一步提高诊断准确性，应用价值更高。
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| 关 键 词： | 胃癌 胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ 胃泌素-17 |
Application of Serum PGI,PGII and G-17 Detection in Early Diagnosis of Gastric Cancer |
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| LIU Bing,YANG Shuai,CHEN Hui.Application of Serum PGI,PGII and G-17 Detection in Early Diagnosis of Gastric Cancer[J].Medical Information,2019,0(22):162-163. |
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| Authors: | LIU Bing YANG Shuai CHEN Hui |
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| Affiliation: | (1.Department of Biochemistry,Baodi District People's Hospital,Tianjin 301800,China;2.Department of Immunology,Baodi District People's Hospital,Tianjin 301800,China;3. Department of Clinical Laboratory,Baodi District Maternity Hospital,Tianjin 301800,China) |
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| Abstract: | Objective To study the application value of serum pepsinogen I (PGI), pepsinogen II (PGII) and gastrin-17 (G-17) in the early diagnosis of gastric cancer. Methods A total of 98 patients with gastric diseases admitted to our hospital from January 2017 to January 2019 were enrolled. Among them, 48 patients with gastric cancer were enrolled in group A, 50 patients with atrophic gastritis were enrolled in group B, and 50 healthy subjects were selected. The patients were treated with PGⅠ, PGⅡ and G-17, and the results of PGⅠ, PGR (PGⅠ/PGⅡ) and G-17 single and combined diagnosis were analyzed by gastroscopy or surgical results. Results The accuracy of combined diagnosis of PGI, PGR and G-17 was higher than that of single test, the difference was statistically significant (P<0.05); the sensitivity of combined diagnosis was higher than that of PGR and G-17, the difference was statistically significant (P<0.05); control group, observation group B, observation group A, PGⅠ, PGR decreased in turn, PGⅡ increased in turn, the difference was statistically significant (P<0.05); observation group A G-17 higher than observation group B,the difference was statistically significant (P<0.05). Conclusion The single detection of serum PGⅠ, PGⅡ and G-17 has certain value in the early diagnosis of gastric cancer, but the combined detection can further improve the diagnostic accuracy and the application value is higher. |
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| Keywords: | Gastric cancer Pepsinogen I Pepsinogen II Gastrin-17 |
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