| 中草药祛痘复方对痤疮致病菌和外泌酶的影响 |
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| 引用本文： | 贺改英,陈 迪,沈 丽.中草药祛痘复方对痤疮致病菌和外泌酶的影响[J].日用化学工业,2018,48(7). |
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| 作者姓名： | 贺改英 陈 迪 沈 丽 |
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| 作者单位： | 莱博药妆技术(上海)股份有限公司 |
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| 摘 要： | 通过药敏试验和抑菌试验考察中草药祛痘复方对痤疮丙酸杆菌(Propionibacterium acnes,PA)、金黄色葡萄球菌(Staphylococcus aureus,SA)和表皮葡萄球菌(Staphylococcus epidermidis,SE)的抑菌功效,同时考察其对3种菌的抑菌时间动力学的影响。采用脂肪酶和蛋白酶水解底物形成的透明圈,研究中草药祛痘复方对PA释放脂肪酶和蛋白酶的影响。结果表明,中草药祛痘复方明显抑制了PA、SA和SE,并呈时间和剂量依赖性关系;中草药祛痘复方抑制脂肪酶和蛋白酶的作用主要是通过抑制PA而发挥作用。
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| 关 键 词： | 化妆品添加剂 中草药祛痘复方 痤疮丙酸杆菌 金黄色葡萄球菌 表皮葡萄球菌 脂肪酶 蛋白酶 |
The effect of Chinese herbal anti-acne formula on pathogenic bacteria and exocrine enzyme of acne vulgaris |
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| Abstract: | The antimicrobial efficacy of Chinese herbal anti-acne formula on Propionibacterium acnes (PA), Staphylococcus aureus (SA), and Staphylococcus epidermidis (SE) were investigated by susceptibility test and bacteriostatic test, and the bacteriostatic kinetics of it on these three bacterial were also examined. A transparent circle formed by lipase and protease hydrolysis substrate was used to study the effect of Chinese herbal anti-acne formula on the release of lipase and protease from PA. The results show that Chinese herbal anti-acne formula significantly inhibits PA, SA and SE in a time-and dose-dependent manner. The inhibitory effect of Chinese herbal anti-acne formula on lipase and protease mainly depends on inhibiting PA. |
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| Keywords: | additives of cosmetics Chinese herbal anti-acne formula propionibacterium acnes staphylococcus aureus staphylococcus epidermidis lipase protease |
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