| 王宝勤,熊景峰,王珏,谭洪玲,涂开成.裂变中子照射对小鼠脾脏淋巴细胞增殖功能的影响[J].中华放射医学与防护杂志,1996,16(2):100-104 |
| 裂变中子照射对小鼠脾脏淋巴细胞增殖功能的影响 |
| Effects of fission-neutron irradiation on proliferation of lymphocytes in murine spleen |
| 投稿时间：1995-01-13 修订日期：1995-04-13 |
| DOI： |
| 中文关键词: 裂变中子 淋巴细胞 增殖功能 小鼠 |
| 英文关键词:Fission neutrons spleen lymphocytes proliferation mice |
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| 中文摘要: |
| 小鼠经梯度剂量的裂变中子和60Coγ射线照射, 照后1天脾脏淋巴细胞数的变化, 显示了其是由对中子和γ射线辐射敏感和辐射抗性两种成分组成, 而同一种成分对中子辐射的敏感性又高于对γ射线的辐射敏感性。对中子和γ射线辐射敏感成分的D0值分别为0.40Gy和0.96Gy,RBE值为2.40.用丝裂原刺激后的3H-TdR掺入法测定照后小鼠脾脏淋巴细胞的增殖反应, 表明脾脏的T、B淋巴细胞也是由辐射敏感性不同的两种成分组成。 |
| 英文摘要: |
| in this paper the proliferative function of splenic lymphocytes in mice irradiated with graded doses of fission neutron was investigated 24h after radiation, using the method of 3M-TdR incorporation after mitogen stimulation.At the same tune, the characteristics of injury and repair of proliferative function after 2. 3Gy neutron irradiation were compared with those after equivalent lethal dose of 60Co γ-rays.The changes in the number of murine splenic lymphocytes indicate that there are two components in it: the radiosensitive and radioresistant to neutron radiation and γ-radiation, the radiosensitivity to neutrons is higher than that toγ-rays in the same component. D0 values of the radiosensitive cells to neutrons and toγ-rays are 0.40 Gy and 0.96 Gy, respectively.Therefore, RBE= 2.40. After radiation the proliferative response curves of splenic lymphocytes stimulated by ConA or by LPS show that both of T and B lymphocytes consist of two different radiosensitive components. D37 value of T cells which possess high sensitivity to neutron irradiation is about 0. 82 Gy, that of B cells about 1.05 Gy. D37 values of T cells and B cells toγ-rays are 0.75 Gy and 2. 38 Gy, respectively. Hence, RBE values are 0. 91 and 2. 27, correspondingly. After irradiation of 2.3 Gy fission-neutrons or 4.5 Gy γ-rays,the tendency of damage and recovery of the transformation function of murine splenic T lymphocytes stimulated by ConA is about the same, and that of B lymphocytes stimulated by LPS has the same pattern. |
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