As for the full scale test for the large diameter deep-hole stoping of 120m high pillars in Anqing Copper Mine, an orthogonality method was used to determine the distance from side-row blasthole to fill and the parameters of explasive-charged structure of side-row blastholes;a mathematical model was established for the blasting of the superhigh pillars so as to optimize the blasting parameters and it was showed that the parameters had achieved good results in the full scale test.