In recent years, with the rapid development of bridge engineering and continuous improvement of bridge traffic network in China, more high-pier bridges have been applied to the practical projects. Taking the high-pier bridge in a practical project as an example, the aseismic design strategy based on cable aseismic bearing is proposed. The seismic isolation design schemes of conventional system and friction pendulum bearings are compared and studied. The bridge structural responses of different schemes under E2 horizontal earthquake are analyzed. The analysis results show that both cable aseismic bearing and friction pendulum bearing adopted in the high-pier bridge can effectively reduce the seismic internal force response of the structure. The friction pendulum bearing and the conventional system may all lead to the larger relative displacement of piers and beams. The cable aseismic bearings can effectively control the relative displacement of pier and beams and prevent the beam falling disasters, which is a reasonable and effective seismic fortification strategy. The study contents can provide the useful reference for aseismic design of high-pier bridges.