| 人参皂甙Rg3抑制肿瘤新生血管形成的研究 |
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| 引用本文： | 高勇,王杰军,许青,叶琴琴,郭静,耿怀成.人参皂甙Rg3抑制肿瘤新生血管形成的研究[J].第二军医大学学报,2001,22(1):40-42. |
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| 作者姓名： | 高勇 王杰军 许青 叶琴琴 郭静 耿怀成 |
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| 作者单位： | 第二军医大学长征医院肿瘤科, |
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| 基金项目： | 上海市科技启明星计划资助项目!(97QBI14 0 2 0 ) |
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| 摘 要： | 目的 :探讨人参皂甙 Rg3抗肿瘤生长的作用机制。方法 :利用鸡胚绒毛尿囊膜 (CAM)观察 Rg3作用后肿瘤新生血管的生长情况 ,并采用 L ewis肺癌模型进一步探讨 Rg3在体内对肿瘤生长及肿瘤新生血管形成的影响。结果 :Rg3浓度为 0 .1和 0 .5 mm ol/L时 ,CAM血管生长抑制指数分别达 (6 2 .4± 9.3) %和 (4 5 .6± 5 .7) % ,与对照组相比差异非常显著 (P<0 .0 1)。对 L ewis肺癌荷瘤小鼠分别以 5、10、2 0 mg/kg的剂量隔日灌胃一次给予 Rg3,连续 10次 ,2 0 d后观察到 3组的肿瘤瘤质量分别为 (1.77± 0 .2 1)、(1.5 8± 0 .17)及 (1.2 2± 0 .2 9) g,与对照组比较有显著性差异 (P <0 .0 1) ,生长抑制率分别为 2 3.0 4%、31.30 %和 47.10 % ,同时观察到 Rg3组的新生血管数也明显减少。 结论 :人参皂甙 Rg3可明显抑制 L ewis肺癌的生长 ,其抑瘤作用部分是因为抑制了肿瘤诱导的新生血管形成
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| 关 键 词： | 人参皂甙RG3 鸡胚 绒毛尿囊膜 肿瘤血管形成 |
| 文章编号： | 0258-879X(2001)01-0040-03 |
| 修稿时间： | 2000年6月26日 |
Inhibitory effect of ginsenoside Rg3 on tumor neoangiogenesis |
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| GAO Yong,WANG Jie-jun,XU Qing,YE Qin-Qin,GUO Jing,GENG Huai-Cheng.Inhibitory effect of ginsenoside Rg3 on tumor neoangiogenesis[J].Academic Journal of Second Military Medical University,2001,22(1):40-42. |
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| Authors: | GAO Yong WANG Jie-jun XU Qing YE Qin-Qin GUO Jing GENG Huai-Cheng |
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| Abstract: | Objective: To study the mechanism of inhibitory effect of ginsenoside Rg3 on tumor growth. Methods: The chick chorioallantoic membrane(CAM) test and Lewis lung carcinoma model were used to investigate the inhibitory effect of Rg3 on tumor angiogenesis. Results: Rg3(0.1 or 0.5 mmol/L) obviously inhibited angiogenesis in the CAM. Treatment with Rg3 in vivo obviously inhibited Lewis lung carcinoma growth with the inhibition ratio from 23% to about 47%. We also observed that the angiogenesis in implanted Lewis lung carcinoma tissue decreased obviously after treated with Rg3 (5, 10, 20 mg/kg). Conclusion: Rg3 can obviously inhibit the growth of Lewis lung cancer, the inhibitory effect partially due to the effect of Rg3 inhibiting neovascularization induced by malignant tumor. |
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| Keywords: | ginsenoside neoplasms vascular tissue chick embryo |
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