According to the characteristics of micro-fractures development and serious CO2 gas channeling in a block of Yaoyingtai oilfield, injection method, injection speed, gas/liquid ratio and frother concentration of supercritical CO2 foam channeling prevention was optimized by experiment. The experimental results showed that: supercritical CO2 foam resistance factor changed greatly under different injection methods and injection at the same time was more advantageous to improve the effect of supercritical CO2 foam channeling prevention; Meanwhile, injection speed, gas/liquid ratio and frother concentration had a significant impact on the effect of supercritical CO2 foam channeling prevention and the optimization results of injection speed was 0.7ml/min, gas/liquid ratio was 1:1, frother concentration was 0.5%.