Abstract:ObjectiveTo study the safety and effectiveness of general anesthesia with no muscle relaxants for endoscopic sinus surgery.Methods160 patients receiving endoscopic sinus surgery under general anesthesia were randomly divided into two groups equally. All patients were intubated after fast induction with intravenous administration of remifentanil, propofol, chlorinated succinylcholine. For maintenance of anesthesia, remifentanil and propofol were administrated intravenously in group A, remifentanil, propofol and vecuronium bromide in group B. Parameters of both groups were recorded, including heart rate (HR), mean arterial blood pressure (MAP), pulse oxygen saturation (SpO2), End tidal carbon dioxide partial pressure(EtCO2), intraoperative body moving times at T1 to T6 observation points, anesthesia recovery time and extubation time, adverse reactions and complications.ResultsDuring T1 to T4, the differences of HR, MAP, SpO2 between both groups were statistically insignificant (P>0.05), and without intraoperative body dynamic response. T5 and T6, the anesthesia recovery time and extubation time of group A were significantly shorter than those of group B (P<0.01). The ratios of hyoxemia, increased secretion, bradycardia occurred in group B were significantly more than those of group A.ConclusionsWith advantages of rapid recovery of respiratory function and protective reflection and avoidance of adverse reactions of muscle relaxants and their antagonists, general anesthesia with remifentanilpropofol but without muscle relaxants is affirmed for endoscopic sinus surgery.