Objective: To study the effect of the six Alpinia Roxbe on phosphodiesterase(PDE), cyclic Adenosine monophosphate(cAMP), cyclic guanosine monophosphate(cGMP), cAMP/cGMP of the gastric tissue of stomachin excessive cold syndrome rats, and reveal the correlation between the six kinds volatile oil of Alpinia Roxb. and the function of warming middle energizer and dispersing cold. Method: By giving cold-cool nature Chinese medicines and freezing method, stomach excessive cold syndrome rat models was established. The high and low dose of the volatile oil and the water extract removed volatile oil of the six Chinese medicine were given to rat, the positive control drug was given water extract of aconite. PDE, cAMP and cGMP,and calculated cAMP/cGMP ratio were determined. Result: ①The high and low dose groups of the volatile oil of the six Chinese medicine significantly reduced the concentration of stomach PDE in model rats(P<0.05 or P<0.01), high dose group of water extract removed volatile oil of Alpinia galanga also had a certain reduction effect, but no significant difference.②The high and low dose groups of the volatile oil of the six Chinese medicine compared with model group, cAMP concentrations were significantly increased (P<0.05 or P<0.01), cGMP no significant changes, cAMP/cGMP ratio increased (P<0.05 or P<0.01);the high dose group of water extract removed volatile oil of galangal, Alpinia katsumadai, Villous amomum fruit also had some influence on the concentration of cAMP, but no significant difference. Conclusion: The volatile oil of the six Alpinia Roxb may elevate gastric tissue cAMP levels, cAMP/cGMP ratio, reduce the PDE content, some Chinese medicine without volatile oil at high dose also had a similar effect. The volatile oil of the six Alpinia Roxb was related the function of warming middle energizer and dispersing cold, and water extract removed volatile oil of the six Chinese medicine also had some good improvement, revealing their effectiveness is also associated with other ingredients contained.