Abstract: According to time-based TVD Runge-Kutta scheme and discretizing governing equations with 5-th order WENO scheme, a high resolution and large scale parallel code was independently developed. With this code, numerical simulation was performed for the propagation characteristics of methane detonation wave in the pipe with concentration gradient. The numerical results show the influence of vertical and horizontal concentration gradient on methane explosion. The numerical simulation results agree well with the theoretical analysis.